Khalil Mohamed, Elsharkawy Nahla, Elmawardy Mona Mohsen, Ayoub Mahmoud Aly
Department of Clinical and Chemical Pathology, National Cancer Institute, Cairo University, Cairo 11796, Egypt.
Diagnostics (Basel). 2023 Jan 16;13(2):325. doi: 10.3390/diagnostics13020325.
Overexpression of CD200 in ALL patients indicates that it may be useful in the characterization of leukemia initiating cells (LIC). We aim at investigating the expression pattern of CD200 on leukemic B cells and the correlation of CD200 expression with various clinical and laboratory findings in 62 newly diagnosed acute lymphoblastic leukemia patients.
All patients were subjected to full history taking, a thorough clinical examination, and laboratory investigations, which included complete blood count (CBC), BM aspiration, immunophenotyping of blast cells, and CD200 expression.
There is a higher statistically significant mean value of CD200 expression among the cases (66.15 ± 23.08) than the control group (0.37 ± 0.2) ( value ≤ 0.001). CD200 expression shows a significant correlation with total leucocytic count and hemoglobin level ( = 0.001, 0.03, respectively).
This study showed that CD200 expression was expressed in 100% of the patients. Correlations between CD200 expression and different laboratory data of patients revealed that there was an impact of CD200 on different diagnostic findings. After the follow-up of the patients, we found that the use of PRISM function of the software could add value to the detection of minimal residual disease.
急性淋巴细胞白血病（ALL）患者中CD200的过表达表明其可能有助于白血病起始细胞（LIC）的特征描述。我们旨在研究62例新诊断的急性淋巴细胞白血病患者白血病B细胞上CD200的表达模式以及CD200表达与各种临床和实验室检查结果的相关性。
所有患者均进行了全面的病史采集、详细的临床检查和实验室检查，包括全血细胞计数（CBC）、骨髓穿刺、原始细胞免疫表型分析以及CD200表达检测。
病例组CD200表达的平均统计学显著值（66.15±23.08）高于对照组（0.37±0.2）（P值≤0.001）。CD200表达与白细胞总数和血红蛋白水平显著相关（分别为P = 0.001，0.03）。
本研究表明100%的患者表达CD200。CD200表达与患者不同实验室数据之间的相关性表明CD200对不同诊断结果有影响。对患者进行随访后，我们发现使用软件的PRISM功能可为微小残留病的检测增加价值。
