Mallick Debjani, Karmakar Rupam, Barui Gopinath, Gon Sonia, Chakrabarti Sudipta
Department of Pathology, ESI PGIMSR & ESIC Medical College, Joka, Diamond Harbour Road, Kolkata, 700104 West Bengal India.
Department of Pathology, RG Kar Medical College, Kolkata, India.
Indian J Hematol Blood Transfus. 2015 Mar;31(1):116-20. doi: 10.1007/s12288-014-0383-3. Epub 2014 Apr 23.
The degree of increase in foetal haemoglobin (HbF) synthesis in haematological malignancies may be associated with the degree of malignancy. The aim of the present study was to quantify HbF levels in various childhood haematological malignancies and also, to ascertain its prognostic significance by comparing the results with the already established standard prognostic factors. Newly diagnosed cases of haematological malignancies in the paediatric age group were included in the study. HbF levels were estimated in each case of the study group along with HbF levels of control group comprising healthy children of same age group. The estimation was done by HPLC and Modified Betke's method. 50 cases of newly diagnosed haematological malignancies were studied out of which most of the cases were of acute lymphoblastic leukaemia (ALL) [n = 30(60 %)] followed by acute myeloid leukaemia (AML) [n = 8(16 %)], Hodgkin's lymphoma [n = 7(14%)], non-Hodgkin's lymphoma [n = 5(10 %)]. Raised HbF levels were found in 43.3 % cases of ALL (13/30) and 37.5 % cases of AML (3/8). No significant rise in HbF level was found in cases of lymphomas. There was correlation between raised HbF level and poor prognostic factors in cases of ALL but no such correlation was found in cases of AML. HbF levels are often elevated in childhood leukaemias as compared to childhood lymphomas. Thus, the concentration of HbF in acute childhood leukaemia may be considered as a prognostic factor.
血液系统恶性肿瘤中胎儿血红蛋白（HbF）合成增加的程度可能与恶性程度相关。本研究的目的是量化各种儿童血液系统恶性肿瘤中的HbF水平，并通过将结果与已确立的标准预后因素进行比较来确定其预后意义。本研究纳入了儿科年龄组新诊断的血液系统恶性肿瘤病例。在研究组的每例病例中估计HbF水平，并与由同年龄组健康儿童组成的对照组的HbF水平进行比较。通过高效液相色谱法（HPLC）和改良的贝特克方法进行测定。研究了50例新诊断的血液系统恶性肿瘤病例，其中大多数病例为急性淋巴细胞白血病（ALL）[n = 30（60%）]，其次是急性髓细胞白血病（AML）[n = 8（16%）]、霍奇金淋巴瘤[n = 7（14%）]、非霍奇金淋巴瘤[n = 5（10%）]。在43.3%的ALL病例（13/30）和37.5%的AML病例（3/8）中发现HbF水平升高。在淋巴瘤病例中未发现HbF水平有显著升高。在ALL病例中，HbF水平升高与不良预后因素之间存在相关性，但在AML病例中未发现这种相关性。与儿童淋巴瘤相比，儿童白血病中HbF水平通常升高。因此，儿童急性白血病中HbF的浓度可被视为一种预后因素。
