Lim Hyeon-Ji, Park In-Sun, Jeong Su-Ji, Ha Gwang-Su, Yang Hee-Jong, Jeong Do-Youn, Kim Seon-Young, Jung Chan-Hun
Jeonju AgroBio-Materials Institute, Wonjangdong-gil 111-27, Jeonju 54810, Republic of Korea.
Microbial Institute for Fermentation Industry, Sunchang 56048, Republic of Korea.
Foods. 2023 Jan 13;12(2):383. doi: 10.3390/foods12020383.
Colorectal cancer (CRC) is the third most common type of cancer and is caused by multiple factors. Chronic inflammation, known to cause inflammatory bowel disease (IBD), is closely associated with CRC. Cheonggukjang (CJ), a traditional Korean fermented soybean, is a functional food with anti-inflammatory effects in the intestines, but its anti-cancer effects have not yet been explored. In this study, we investigated the cancer-protective effects of cheonggukjang in an azoxymethane/DSS (AOM/DSS)-induced colitis-associated colorectal cancer (CAC) mouse model. The CJ alleviated AOM/DSS-induced pathological symptoms such as colonic shortening, increased spleen weight, tumor formation, and histological changes. It also modulated pro-inflammatory and anti-inflammatory cytokine levels via the suppression of NF-κB and inflammatory mediator signaling pathways. Furthermore, the CJ improved intestinal integrity by regulating mucin-associated and tight junction proteins. In addition, it suppressed tumor growth by regulating apoptosis and proliferation. These results highlight the anti-tumor effects of CJ in an AOM/DSS-induced CAC mouse model.
结直肠癌（CRC）是第三大常见癌症类型，由多种因素引起。已知会导致炎症性肠病（IBD）的慢性炎症与结直肠癌密切相关。韩国传统发酵大豆清国酱（CJ）是一种在肠道具有抗炎作用的功能性食品，但其抗癌作用尚未得到探索。在本研究中，我们在氧化偶氮甲烷/葡聚糖硫酸钠（AOM/DSS）诱导的结肠炎相关结直肠癌（CAC）小鼠模型中研究了清国酱的癌症保护作用。清国酱减轻了AOM/DSS诱导的病理症状，如结肠缩短、脾脏重量增加、肿瘤形成和组织学变化。它还通过抑制NF-κB和炎症介质信号通路来调节促炎和抗炎细胞因子水平。此外，清国酱通过调节粘蛋白相关蛋白和紧密连接蛋白改善肠道完整性。此外，它通过调节细胞凋亡和增殖来抑制肿瘤生长。这些结果突出了清国酱在AOM/DSS诱导的CAC小鼠模型中的抗肿瘤作用。
