Rosca Ciprian Ilie, Sharma Abhinav, Nisulescu Daniel-Dumitru, Otiman Gabriela, Duda-Seiman Daniel-Marius, Morariu Stelian Ioan, Lighezan Daniel Florin, Kundnani Nilima Rajpal
Centre for Advanced Research in Cardiovascular Pathology and Hemostasis, Victor Babes University of Medicine and Pharmacy, 300041 Timisoara, Romania.
Department of Internal Medicine I-Medical Semiotics I, Victor Babes University of Medicine and Pharmacy, 300041 Timisoara, Romania.
Healthcare (Basel). 2023 Jan 6;11(2):175. doi: 10.3390/healthcare11020175.
Background: Atrial fibrillation (AF) is the most frequent of all cardiac arrhythmias, with an increasing prevalence in the last 20 years. Cardio-embolic brain complications (CEBC) related to AF often occur or recur, even following appropriate treatment. Method: We conducted a retrospective study and analyzed the presence of stroke, dementia, and Parkinson’s disease (PD) in both paroxysmal and permanent AF patients. The records of 1111 consecutive admitted patients with primary diagnosis of AF at the Municipal Emergency University Hospital, Timisoara, between 2015 and 2016 were examined. Statistical analysis was performed on the patients included in the study based on the inclusion and exclusion criteria. Results: A significant statistical difference was noted among the permanent AF group for stroke (48.75% vs. 26.74%, p < 0.001) and dementia (10.25% vs. 3.86%, p < 0.001) compared to paroxysmal AF patients. Permanent AF patients presented a higher risk of developing stroke, dementia, and PD compared to patients with paroxysmal AF. Meanwhile, male gender and an increase in age showed an increase in the odds of having cardio-embolic brain complications in patients with paroxysmal AF. Conclusion: Based on the results obtained, it can be concluded that the risk of cardio-cerebral embolic complications is greater in permanent AF patients compared to paroxysmal AF cases. Ischemic stroke and dementia are more frequent in the permanent AF group, but analyzing the data regarding the age of onset paroxysmal AF is critical due to the fact that it involves a younger population. Prompt diagnosis and treatment can help significantly in saving stroke patients.
心房颤动（AF）是所有心律失常中最常见的一种，在过去20年中其患病率呈上升趋势。与AF相关的心脏栓塞性脑并发症（CEBC）经常发生或复发，即使在经过适当治疗后也是如此。方法：我们进行了一项回顾性研究，分析了阵发性和永久性AF患者中中风、痴呆和帕金森病（PD）的情况。检查了2015年至2016年期间在蒂米什瓦拉市立急诊大学医院连续收治的1111例初步诊断为AF的患者的记录。根据纳入和排除标准对纳入研究的患者进行统计分析。结果：与阵发性AF患者相比，永久性AF组在中风（48.75%对26.74%，p<0.001）和痴呆（10.25%对3.86%，p<0.001）方面存在显著统计学差异。与阵发性AF患者相比，永久性AF患者发生中风、痴呆和PD的风险更高。同时，男性性别和年龄增加表明阵发性AF患者发生心脏栓塞性脑并发症的几率增加。结论：根据所得结果，可以得出结论，与阵发性AF病例相比，永久性AF患者发生心脑栓塞并发症的风险更大。缺血性中风和痴呆在永久性AF组中更为常见，但由于阵发性AF涉及较年轻人群，因此分析其发病年龄的数据至关重要。及时诊断和治疗对挽救中风患者有很大帮助。
