贫血对常压和高压条件下肿瘤放射敏感性的影响。

Effect of anemia on tumor radiosensitivity under normo and hyperbaric conditions.

作者信息

Rojas A, Stewart F A, Smith K A, Soranson J A, Randhawa V S, Stratford M R, Denekamp J

机构信息

Cancer Research Campaign, Gray Laboratory, Mount Vernon Hospital, Northwood, Middlesex, U.K.

出版信息

Int J Radiat Oncol Biol Phys. 1987 Nov;13(11):1681-9. doi: 10.1016/0360-3016(87)90165-9.

DOI:10.1016/0360-3016(87)90165-9

PMID:3667375

Abstract

The effect of chronic anemia on tumor radiosensitivity in a murine tumor has been investigated. Anemia was induced by bilateral kidney irradiation given several months before tumor implantation. Anemic, anemic transfused, and normal non-anemic age-matched tumor bearing animals were irradiated with X rays (2 F/24 hr) either in air, air plus misonidazole, or under hyperbaric oxygen. The most resistant response was that of tumors grown in normal mice treated in air. Anemia produced an increase in radiosensitivity which was further enhanced by red blood cell replacement. The most sensitive overall response was seen in the anemic-transfused group treated with HBO.

摘要

已对慢性贫血对小鼠肿瘤放射敏感性的影响进行了研究。在肿瘤植入前数月通过双侧肾脏照射诱导贫血。对贫血、输血治疗的贫血以及年龄匹配的正常非贫血荷瘤动物，分别在空气中、空气加米索硝唑或高压氧条件下进行X射线照射（2次分割/24小时）。最具抗性的反应是在空气中处理的正常小鼠体内生长的肿瘤的反应。贫血导致放射敏感性增加，而红细胞替代进一步增强了这种增加。在用高压氧治疗的贫血输血组中观察到了最敏感的总体反应。