Stone H B, Milas L
Department of Radiation Oncology, University of California, San Francisco 94143.
Int J Radiat Oncol Biol Phys. 1987 Nov;13(11):1721-4. doi: 10.1016/0360-3016(87)90169-6.
Normal tissue damage in the legs of mice was enhanced by the presence of a fibrosarcoma (FSa I) in the leg at the time of treatment with single doses of 30 to 70 Gy. Damage was assessed by measuring leg contracture 23 to 365 days after irradiation of 8 mm diameter tumors. Animals with and without tumors were treated with 1.0 mg misonidazole/g body weight 30 min before irradiation to ensure that the tumors did not recur and interfere with the assessment of contracture. The data suggest that in some cases, late damage may be enhanced by destructive effects of the tumor on the tumor bed.
在用单剂量30至70 Gy进行治疗时，腿部存在纤维肉瘤（FSa I）会增强小鼠腿部的正常组织损伤。在对直径8毫米的肿瘤进行照射后23至365天，通过测量腿部挛缩来评估损伤情况。在照射前30分钟，给有肿瘤和无肿瘤的动物按1.0毫克米索硝唑/克体重进行处理，以确保肿瘤不会复发并干扰挛缩评估。数据表明，在某些情况下，肿瘤对肿瘤床的破坏作用可能会增强晚期损伤。
