Fu K K, Lam K N
Department of Radiation Oncology, University of California, San Francisco 94143.
Int J Radiat Oncol Biol Phys. 1991 Feb;20(2):327-32. doi: 10.1016/0360-3016(91)90114-j.
The influence of radiation dose rate and drug dose on the combined effects of cisplatin (Cis-diamminedichloroplatinum (II] and radiation on the skin and soft tissues was studied in the C3Hf/SED mice. Localized acute-dose-rate irradiation (ADRI) at 3.345 Gy/min and continuous low-dose-rate irradiation (CLDRI) of the hind leg at 0.028 Gy/min with and without the drug was delivered using a 137Cs laboratory irradiator. Cisplatin at 6 or 11 mg/kg was given by intraperitoneal bolus injection 1 hour before ADRI or by continuous infusion during CLDRI. Acute skin reaction was scored from days 13 to 30 and late skin contraction and leg contracture were measured at days 90, 180, 270, and 360 after treatment. A marked dose-rate effect was observed for these early and late normal tissue endpoints. At a dose of 60 Gy of CLDRI, the dose rate factor (DRF = isoeffect dose at CLDRI/isoeffect dose at ADRI) was 1.82 for acute skin reaction and 1.76 for late skin contraction or leg contracture at day 270. However, there was no significant enhancement of these early and late normal tissue effects by cisplatin at 6 or 11 mg/kg at either acute or low dose rates. Thus neither drug dose nor radiation dose rate had a significant impact on the combined effects of cisplatin and radiation on the mouse skin and soft tissues of the leg.
在C3Hf/SED小鼠中研究了辐射剂量率和药物剂量对顺铂（顺二氯二氨合铂（II））与辐射联合作用于皮肤和软组织的影响。使用137Cs实验室辐照器，以3.345 Gy/min的剂量进行局部急性剂量率照射（ADRI），并以0.028 Gy/min的剂量对后腿进行连续低剂量率照射（CLDRI），照射时使用或不使用药物。在ADRI前1小时通过腹腔推注给予6或11 mg/kg的顺铂，或在CLDRI期间进行连续输注。在治疗后第13至30天对急性皮肤反应进行评分，并在治疗后第90、180、270和360天测量晚期皮肤收缩和腿部挛缩情况。对于这些早期和晚期正常组织终点，观察到了明显的剂量率效应。在CLDRI剂量为60 Gy时，急性皮肤反应的剂量率因子（DRF = CLDRI等效剂量/ADRI等效剂量）为1.82，在第270天晚期皮肤收缩或腿部挛缩的剂量率因子为1.76。然而，在急性或低剂量率下，6或11 mg/kg的顺铂均未显著增强这些早期和晚期正常组织效应。因此，药物剂量和辐射剂量率对顺铂与辐射联合作用于小鼠腿部皮肤和软组织均无显著影响。
