Department for Urgent and Intensive Medicine with Clinical Pharmacology and Toxicology, Internal Medicine Clinic, University Hospital Split, University of Split School of Medicine, 21000 Split, Croatia.
Department of Endocrinology, Internal Medicine Clinic, University Hospital Split, University of Split School of Medicine, 21000 Split, Croatia.
Int J Environ Res Public Health. 2023 Jan 9;20(2):1136. doi: 10.3390/ijerph20021136.
Introduction: Catestatin (CST) is a peptide with immunomodulatory, anti-inflammatory, and anti-microbial activities. There are only a few studies that have investigated plasma CST levels in COVID-19 patients (mostly in ICU patients). In our work, the aim was to demonstrate serum CST levels and their correlation with clinical outcomes in a group of severe COVID-19 patients admitted to the non-ICU department. Methods: The subjects were 32 patients (25 females, 7 males) admitted to the non-ICU unit for COVID-19 patients. Results: CST levels in our cohort were higher (8.91 ± 7.00) than previously reported CST levels in control subjects. We found a significant positive correlation between serum CST levels and C-reactive protein (r = 0.423, p = 0.008), D-dimers (r = 0.395, p = 0.013), hsTNT (high-sensitivity troponin T) (r = 0.603, p < 0.001), proBNP (N-terminal pro-brain natriuretic peptide) (r = 0.569, p < 0.001), and hospitalization days (r = 0.388, p = 0.014). There was a difference between groups of participants with SOFA <3 (n = 18) and SOFA >=3 (n = 14) in catestatin serum levels (7.25 ± 3.66 vs. 11.05 ± 9.52 ng/mL), but the difference was statistically insignificant (p = 0.065). Conclusion: We considered plasma CST level at hospital admission as a possible tool for early risk assessment in non-critical COVID-19 patients. This study is an attempt to clarify the complex pathophysiological mechanisms present in the development of severe forms of SARS-CoV2 infection.
Catestatin（CST）是一种具有免疫调节、抗炎和抗微生物活性的肽。只有少数研究调查了 COVID-19 患者（主要是 ICU 患者）的血浆 CST 水平。在我们的工作中，目的是在一组入住非 ICU 病房的严重 COVID-19 患者中证明血清 CST 水平及其与临床结局的相关性。
研究对象为 32 名（25 名女性，7 名男性）因 COVID-19 入住非 ICU 病房的患者。
我们队列中的 CST 水平高于以前报道的对照组中的 CST 水平（8.91±7.00）。我们发现血清 CST 水平与 C-反应蛋白（r=0.423，p=0.008）、D-二聚体（r=0.395，p=0.013）、hsTNT（高敏肌钙蛋白 T）（r=0.603，p<0.001）、proBNP（N-末端脑钠肽前体）（r=0.569，p<0.001）和住院天数（r=0.388，p=0.014）之间存在显著正相关。SOFA<3（n=18）和 SOFA>=3（n=14）两组参与者的 CST 血清水平存在差异（7.25±3.66 vs. 11.05±9.52ng/mL），但差异无统计学意义（p=0.065）。
我们认为入院时的血浆 CST 水平可作为非危重症 COVID-19 患者早期风险评估的一种可能工具。本研究试图阐明 SARS-CoV2 感染严重形式发展中存在的复杂病理生理机制。
