School of Public Health, Wuhan University, Wuhan 430000, China.
College of Life Sciences, Wuhan University, Wuhan 430000, China.
Int J Environ Res Public Health. 2023 Jan 10;20(2):1271. doi: 10.3390/ijerph20021271.
PM has an aerodynamic diameter of less than or equal to 2.5 microns due to its inherent physical and chemical properties so that it can enter the alveoli through the respiratory tract for blood gas exchange. Numerous studies have shown that PM is a serious air pollutant that poses a wide range of health risks, especially for cancer. Bibliometric methods were employed to have comprehensively analyzed the research of PM in cancer for about a decade in Web of Science to identify hotspots and trends using VOSviewer, CiteSpace, and R. The field has undergone overall growth in the past decade. As research on PM in health deepens, cancer related to it expanded beyond the respiratory system to the digestive system, urinary system, female gonadal axis, breast cancer and other cancers. Another observation is that research on PM in cancer has progressed in the mechanisms of deterioration, such as the role of matrix metalloproteinases in cancer. In addition, research on the risks of PM in combination with polycyclic aromatic hydrocarbons and heavy metals has also emerged. Results showed that there are relatively more studies on PM in high-latitude countries, which may be due to different national conditions, such as climate and coal combustion. Our research has combed through the progress of PM in cancer research and provided a supplement for developing pollution prevention ideas with different national conditions in this field.
由于其固有物理和化学性质,PM 的空气动力学直径小于或等于 2.5 微米,因此可以通过呼吸道进入肺泡进行血气交换。大量研究表明,PM 是一种严重的空气污染物,对健康构成广泛威胁,尤其是对癌症。本研究采用文献计量学方法,利用 VOSviewer、CiteSpace 和 R 对 Web of Science 中近十年来关于 PM 与癌症的研究进行了全面分析,以确定热点和趋势。过去十年,该领域的研究整体呈增长趋势。随着 PM 在健康领域研究的深入,与 PM 相关的癌症研究已从呼吸系统扩展到消化系统、泌尿系统、女性性腺轴、乳腺癌等癌症。另一个观察结果是,PM 恶化机制方面的研究也取得了进展,例如基质金属蛋白酶在癌症中的作用。此外,PM 与多环芳烃和重金属结合的风险研究也已出现。结果表明,高纬度国家的 PM 研究相对较多,这可能是由于不同的国情,如气候和煤炭燃烧等。本研究梳理了 PM 与癌症研究的进展,为该领域根据不同国情制定污染防治思路提供了补充。