Addictive Substance Project, Tokyo Metropolitan Institute of Medical Science, Tokyo 156-8506, Japan.
Department of Dental Anesthesiology, Tokyo Dental College, Tokyo 101-0061, Japan.
Int J Mol Sci. 2023 Jan 5;24(2):1028. doi: 10.3390/ijms24021028.
Chronic pain is reportedly associated with the transient receptor potential canonical 3 () gene. The present study examined the genetic associations between the single-nucleotide polymorphisms (SNPs) of the gene and chronic pain. The genomic samples from 194 patients underwent linkage disequilibrium (LD) analyses of 29 SNPs within and around the vicinity of the gene. We examined the associations between the SNPs and the susceptibility to chronic pain by comparing the genotype distribution of 194 patients with 282 control subjects. All SNP genotype data were extracted from our previous whole-genome genotyping results. Twenty-nine SNPs were extracted, and a total of four LD blocks with 15 tag SNPs were observed within and around the gene. We further analyzed the associations between these tag SNPs and chronic pain. The rs11726196 SNP genotype distribution of patients was significantly different from the control subjects even after multiple-testing correction with the number of SNPs. The TT + TG genotype of rs11726196 is often carried by chronic pain patients, suggesting a causal role for the T allele. These results contribute to our understanding of the genetic risk factors for chronic pain.
慢性疼痛据报道与瞬时受体电位经典型 3 () 基因有关。本研究探讨了 基因单核苷酸多态性 (SNP) 与慢性疼痛之间的遗传关联。194 例患者的基因组样本进行了 基因内和附近的 29 个 SNP 的连锁不平衡 (LD) 分析。我们通过比较 194 例患者和 282 例对照的基因型分布，来检测 SNP 与慢性疼痛易感性之间的关联。所有 SNP 基因型数据均从我们之前的全基因组基因分型结果中提取。提取了 29 个 SNP，共观察到 基因内和附近有 15 个标签 SNP 的 4 个 LD 块。我们进一步分析了这些标签 SNP 与慢性疼痛之间的关联。即使在对 SNP 数量进行多次检验校正后，患者的 rs11726196 SNP 基因型分布仍与对照组有显著差异。rs11726196 的 TT+TG 基因型常被慢性疼痛患者携带，提示 T 等位基因可能起因果作用。这些结果有助于我们理解慢性疼痛的遗传风险因素。
