Advanced Glycoscience Research Cluster (AGRC), University of Galway, H91 W2TY Galway, Ireland.
CÚRAM, SFI Research Centre for Medical Devices, Biomedical Sciences, University of Galway, H91 W2TY Galway, Ireland.
Int J Mol Sci. 2023 Jan 7;24(2):1200. doi: 10.3390/ijms24021200.
The potential for psychedelic molecules in impacting cognitive flexibility has long been supported and acknowledged across scientific reports. In the current study, an approach leveraging knowledge-based gene-set information analysis has been adopted to explore the potential impact of psychedelic molecules on both glycosylation, (a post-translational modifications (PTM)) and on neuro-regulatory pathways. Though limitations and restrictions rise from the scarcity of publicly available 'omics' data, targeted analysis enabled us to identify a number of key glycogenes (, , , , , ) involved the structural organization of extracellular matrix and neuroprotective factors (, , , , , ) which play vital roles in neuron protection, development as well as synaptic stability. In response to psychedelic molecules, we found that these genes and associated pathways are transcriptional altered in rodent models. The approach used indicates the potential to exploit existing datasets for hypothesis generation and testing for the molecular processes which play a role in the physiological response to psychedelic molecule effects. These reported findings, which focused on alterations in glycogenes and neuro-regulatory factors may provide a novel range of biomarkers to track the beneficial, as well as potential toxicological effects of psychedelic molecules.
迷幻分子在影响认知灵活性方面的潜力在科学报告中得到了长期的支持和认可。在当前的研究中，我们采用了一种利用基于知识的基因集信息分析的方法，来探索迷幻分子对糖基化（一种翻译后修饰（PTM））和神经调节途径的潜在影响。尽管由于缺乏公开可用的“组学”数据，存在一些限制和约束，但有针对性的分析使我们能够识别出一些关键的糖基基因（、、、、、），这些基因参与细胞外基质的结构组织和神经保护因子（、、、、、）的调节，而这些因子在神经元保护、发育以及突触稳定性方面起着至关重要的作用。在对迷幻分子的反应中，我们发现这些基因和相关途径在啮齿动物模型中发生了转录变化。所使用的方法表明，有可能利用现有数据集来生成假设并对分子过程进行测试，这些分子过程在对迷幻分子作用的生理反应中发挥作用。这些报告的发现，重点关注糖基基因和神经调节因子的改变，可能为跟踪迷幻分子的有益和潜在毒理学作用提供一系列新的生物标志物。
