常见变异与偏头痛风险之间缺乏关联。
Lack of Association between Common Variants and Risk of Migraine.
机构信息
University Institute of Molecular Pathology Biomarkers, ARADyAL. Instituto de Salud Carlos III, Universidad de Extremadura, E-10071 Cáceres, Spain.
Section of Neurology, Hospital La Mancha-Centro, E-13600 Alcázar de San Juan, Spain.
出版信息
Int J Mol Sci. 2023 Jan 9;24(2):1292. doi: 10.3390/ijms24021292.
Several papers have been published suggesting a probable role of inflammatory factors in the etiopathogenesis of migraine. In this study, we investigated the possible association between common variants in the genes (both genes, which are closely related, encode proteins involved in inflammatory and autoimmune responses) in the risk of migraine in a cohort of Caucasian Spanish participants. For this purpose, the frequencies of rs1922452, rs951818, and rs870849 genotypes and allelic variants, using a specific -based qPCR assay, were assessed in 290 patients diagnosed with migraine and in 300 healthy controls. The relationship of these variables with several clinical features of migraine was also analyzed. The frequencies of the analyzed genotypes did not differ significantly between the two study groups and were not related to the sex, age at onset of migraine, family history of migraine, presence or absence of aura, or the triggering effect of ethanol on migraine episodes. These results suggest a lack of association between common variants in the genes and the risk of developing migraine in the Caucasian Spanish population.
已有几篇论文表明，炎症因子可能在偏头痛的病因发病机制中起作用。在这项研究中，我们调查了在一个西班牙白种人队列中， 基因（这两个基因编码参与炎症和自身免疫反应的蛋白质）的常见变异与偏头痛风险之间的可能关联。为此，我们使用特定的基于 qPCR 的测定法，评估了 290 名偏头痛患者和 300 名健康对照者中 rs1922452、rs951818 和 rs870849 基因型和等位基因变异的频率。还分析了这些变量与偏头痛的几种临床特征之间的关系。在两个研究组之间，分析的基因型频率没有显著差异，且与偏头痛的发病性别、年龄、偏头痛家族史、有无先兆以及乙醇对偏头痛发作的触发作用均无关。这些结果表明，在西班牙白种人群中， 基因的常见变异与偏头痛的发病风险之间不存在关联。
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