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2020 - 2022年希腊北部的新型冠状病毒肺炎相关肺曲霉病(CAPA):根据主要共识标准和定义的比较研究

COVID-19-Associated Pulmonary Aspergillosis (CAPA) in Northern Greece during 2020-2022: A Comparative Study According to the Main Consensus Criteria and Definitions.

作者信息

Siasios Panagiotis, Arvaniti Kostoula, Zachrou Evangelia, Poulopoulou Aikaterini, Pisanidou Pinelopi, Vasileiadou Georgia, Kaimakamis Evangelos, Georgopoulou Athina, Renta Foteini, Lathyris Dimitrios, Veroniki Foteini, Geka Eleni, Soultati Ioanna, Argiriadou Eleni, Apostolidou Eleni, Amoiridou Pinelopi, Ioannou Konstantinos, Kouras Leonidas, Mimitou Ioanna, Stokkos Konstantinos, Flioni Elliniki, Pertsas Evangelos, Sileli Maria, Iasonidou Christina, Sourla Evdokia, Pitsiou Georgia, Vyzantiadis Timoleon-Achilleas

机构信息

Department of Microbiology, Medical School, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece.

ICU, "Papageorgiou" General Hospital of Thessaloniki, 56403 Thessaloniki, Greece.

出版信息

J Fungi (Basel). 2023 Jan 5;9(1):81. doi: 10.3390/jof9010081.

Abstract

Coronavirus disease 2019 (COVID-19)-associated pulmonary aspergillosis (CAPA) has emerged as an important complication among patients with acute respiratory failure due to SARS-CoV-2 infection. Almost 2.5 years since the start of the COVID-19 pandemic, it continues to raise concerns as an extra factor that contributes to increased mortality, which is mostly because its diagnosis and management remain challenging. The present study utilises the cases of forty-three patients hospitalised between August 2020 and February 2022 whose information was gathered from ten ICUs and special care units based in northern Greece. The main aim was to describe the gained experience in diagnosing CAPA, according to the implementation of the main existing diagnostic consensus criteria and definitions, and present the different classification of the clinical cases due to the alternative algorithms.

摘要

2019冠状病毒病(COVID-19)相关肺曲霉病(CAPA)已成为严重急性呼吸综合征冠状病毒2(SARS-CoV-2)感染所致急性呼吸衰竭患者的一种重要并发症。自COVID-19大流行开始至今已近2.5年,它作为导致死亡率增加的一个额外因素,仍令人担忧,这主要是因为其诊断和管理仍然具有挑战性。本研究采用了2020年8月至2022年2月期间住院的43例患者的病例,这些病例信息来自希腊北部的10个重症监护病房和特殊护理病房。主要目的是根据主要现有诊断共识标准和定义的实施情况,描述在诊断CAPA方面获得的经验,并展示由于替代算法导致的临床病例的不同分类。

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