Ghizlane El Aidouni, Manal Merbouh, Abderrahim El Kaouini, Abdelilah Elrhalete, Mohammed Maarad, Rajae Alkouh, Amine Bouazzaoui Mohammed, Houssam Bkiyar, Naima Abda, Brahim Housni
Intensive Care Unit, Mohammed VI University Hospital Center, Oujda, Morocco.
Mohammed First University Oujda, Faculty of Medicine and Pharmacy, Oujda, Morocco.
Ann Med Surg (Lond). 2021 Sep;69:102816. doi: 10.1016/j.amsu.2021.102816. Epub 2021 Sep 8.
Lymphopenia is one of features that helps identify patients with severe Covid-19. This retrospectively study analyzed the association of lymphopenia with the severity of COVID-19 infection, determinate the predictive factors of lymphopenia and the significance of mortality in patient with lymphopenia.
This retrospective study included patients diagnosed with Covid-19 and admitted to intensive care unit of our university hospital center From Mars 1st 2020, to December 31st 2020.
In this study, 589 patients were included, a group had lymphopenia with 357 cases (60.06%) and the non-lymphopenia group with 232 cases (39.4%). The median age of our patients having lymphopenia was 65 years (56-76). Hypertension and diabetes were noted in the majority of patients with lymphopenia than in the non-lymphopenia group. Lymphopenia was strongly correlated to the inflammatory biomarkers of COVID-19 and were significant. A significant correlation was found between lymphopenia group and CT scan. Lymphopenia was observed as an indicator of prolonged duration of hospitalization but was not significant.
Analytical data from this retrospective study shows the importance in the association between lymphopenia and the severity of COVID-19 infection, hence the need for dynamic monitoring of the number of lymphocytes on admission and during hospitalization of these patients.
淋巴细胞减少是有助于识别重症新型冠状病毒肺炎（Covid-19）患者的特征之一。本回顾性研究分析了淋巴细胞减少与Covid-19感染严重程度的相关性，确定淋巴细胞减少的预测因素以及淋巴细胞减少患者的死亡率意义。
本回顾性研究纳入了2020年3月1日至2020年12月31日期间在我校医院中心重症监护病房确诊为Covid-19的患者。
本研究共纳入589例患者，其中淋巴细胞减少组357例（60.06%），非淋巴细胞减少组232例（39.4%）。淋巴细胞减少患者的中位年龄为65岁（56 - 76岁）。与非淋巴细胞减少组相比，大多数淋巴细胞减少患者患有高血压和糖尿病。淋巴细胞减少与Covid-19的炎症生物标志物密切相关且具有显著性。淋巴细胞减少组与CT扫描之间存在显著相关性。淋巴细胞减少被视为住院时间延长的一个指标，但不具有显著性。
这项回顾性研究的分析数据表明淋巴细胞减少与Covid-19感染严重程度之间关联的重要性，因此需要在这些患者入院时及住院期间动态监测淋巴细胞数量。
