Kim Young-Seong, Baek Jin Woo, Jin Zhengyun, Jeon Hee Chang, Han Min-Woo, Lim Joong Yeon
Department of Mechanical, Robotics and Energy Engineering, Dongguk University, Seoul 04620, Republic of Korea.
Quantum Functional Semiconductor Research Center, Dongguk University, Seoul 04620, Republic of Korea.
Materials (Basel). 2023 Jan 12;16(2):739. doi: 10.3390/ma16020739.
Several composite materials are being investigated as reinforcement fillers for surgery simulations. This study presents an artificial composite material with properties similar to those of the human bone, which may be used in surgery simulations. Moreover, considering the potential toxicity of debris generated during sawing, a safe epoxy-based composite material was synthesized using cellulose nanocrystals (CNCs) and bioceramics (i.e., hydroxyapatite, Yttria stabilized zirconia oxide, Zirconia oxide), which were used to mimic the stiffness of human bone. To examine the change in mechanical properties according to the composition, 1, 3, and 5 wt% of CNCs were mixed with 5 wt% of the bioceramics. When CNCs were added at 1 wt%, there was a confirmed change in the non-linear stiffness and ductility. The CNC-added specimen fractured when forming a nano-network around the local CNCs during curing. In contrast, the specimen without CNCs was more densely structured, and combined to form a network of all specimens such that a plastic region could exist. Thus, this study successfully manufactured a material that could mimic longitudinal and transverse characteristics similar to those of real human bone, as well as exhibit mechanical properties such as strength and stiffness. Bioceramics are harmless to the human body, and can be used by controlling the added quantity of CNCs. We expect that this material will be suitable for use in surgery simulations.
几种复合材料正在作为手术模拟的增强填料进行研究。本研究提出了一种性能与人骨相似的人工复合材料，可用于手术模拟。此外，考虑到锯切过程中产生的碎屑的潜在毒性，使用纤维素纳米晶体（CNC）和生物陶瓷（即羟基磷灰石、氧化钇稳定的氧化锆、氧化锆）合成了一种安全的环氧基复合材料，用于模拟人骨的硬度。为了研究根据组成的机械性能变化，将1、3和5 wt%的CNC与5 wt%的生物陶瓷混合。当添加1 wt%的CNC时，非线性刚度和延展性有明显变化。添加CNC的试样在固化过程中围绕局部CNC形成纳米网络时发生断裂。相比之下，未添加CNC的试样结构更致密，并结合形成所有试样的网络，从而可能存在塑性区域。因此，本研究成功制造出一种能够模拟与真实人骨相似的纵向和横向特性，并具有强度和刚度等机械性能的材料。生物陶瓷对人体无害，可通过控制CNC的添加量来使用。我们预计这种材料将适用于手术模拟。
