Department of Neuroscience DNS, Otolaryngology Section, University of Padova, 35100 Padova, Italy.
ENT Unit, Surgical Department, Ospedali Riuniti Padova Sud, 35043 Monselice-Padova, Italy.
Medicina (Kaunas). 2023 Jan 8;59(1):123. doi: 10.3390/medicina59010123.
Chronic otitis media (COM) and chronic rhinosinusitis (CRS) are two of the most common otolaryngological disorders. CRS and COM share pathophysiological mechanisms such as bacterial infection, biofilm, and the persistence of the obstruction state of ventilation routes. The purpose of this systematic review was to evaluate all available information on the association between COM and CRS. : The protocol of this investigation was registered on PROSPERO in November 2022. Pubmed, Scopus, Web of Science, and Cochrane databases were systematically searched according to the PRISMA statement. After the application of inclusion-exclusion criteria, four manuscripts with adequate relevance to this topic were included in the review. The study population consisted of 20,867 patients with a diagnosis of CRS, of whom 991 were also diagnosed with COM (4.75%). : The included studies have shown that CRS has become significantly associated with COMas: a global inflammatory process that involves the epithelium in both the middle ear and upper airway. The identification of a relationship between CRS and COM may contribute to preventing chronic inflammatory conditions through the early management of the associated disease. Further, carefully designed studies are necessary to demonstrate the relationship between COM and CRS.
慢性中耳炎（COM）和慢性鼻-鼻窦炎（CRS）是两种最常见的耳鼻喉科疾病。CRS 和 COM 具有共同的病理生理机制，如细菌感染、生物膜和通气道阻塞状态的持续存在。本系统评价的目的是评估 COM 和 CRS 之间所有相关信息。：本研究方案于 2022 年 11 月在 PROSPERO 上注册。根据 PRISMA 声明，系统地检索了 PubMed、Scopus、Web of Science 和 Cochrane 数据库。在应用纳入排除标准后，纳入了 4 篇与该主题相关的充分研究。研究人群包括 20867 例确诊为 CRS 的患者，其中 991 例同时诊断为 COM（4.75%）。：纳入的研究表明，CRS 与 COM 明显相关，因为：这是一种涉及中耳和上呼吸道上皮的全身性炎症过程。识别 CRS 和 COM 之间的关系有助于通过早期管理相关疾病来预防慢性炎症性疾病。此外，还需要精心设计的研究来证明 COM 和 CRS 之间的关系。
