Department of Otorhinolaryngology, Head and Neck Diseases, School of Medicine, University of Warmia and Mazury in Olsztyn, al. Warszawska 30, 10-082 Olsztyn, Poland.
Medicina (Kaunas). 2023 Jan 19;59(2):201. doi: 10.3390/medicina59020201.
: Aerosol drug administration is the primary treatment modality of otitis media with effusion (OME). An automatic manosonic aerosol generator (AMSA) delivers, with an acoustic overpressure, a therapeutic dosage of a drug by inhalation of the aerosol. However, available studies confirming their efficacy, especially in adults, are limited. Therefore, this pilot single-arm trial aimed to analyze changes in adults with OME following AMSA treatment. : A group of 36 patients (mean age 51.4 years) with OME underwent a three-day treatment with inhaled mucolytic and steroids administered by AMSA. Tympanometry (tympanogram type, volume, compliance, pressure, and gradient) was performed to measure middle ear effusion before and after the intervention. : Following the intervention, partial and complete OME remission was observed in, respectively, 29 (81%) and 14 (39%) patients. The tympanogram type of the affected ears differed between baseline and after intervention measurements ( < 0.001). Tympanometry-based normalization, improvement deterioration and no change were observed in, respectively, 34 (68%), 1 (2%) 2 (4%), and 13 (26%) affected ears. Following the intervention, we observed an increase in continuously assessed middle ear volume (∆ 0.19 mL, = 0.002) and pressure (∆ 142 daPa, < 0.001), as well as a higher proportion of patients achieving categorical normalization of compliance (16% vs. 54%, < 0.001) and pressure (28 vs. 64%, < 0.001). : Treatment efficacy was not affected by age, sex, or season of recruitment (all > 0.05). The results of this pilot study are encouraging, however, the use of AMSA management of OME in adults needs to be verified in future studies.
: 气雾剂给药是分泌性中耳炎（OME）的主要治疗方式。自动声气溶胶发生器（AMSA）通过吸入气溶胶以声超压输送治疗剂量的药物。然而，目前证实其疗效的研究，特别是在成年人中，非常有限。因此，这项单臂试验旨在分析 AMSA 治疗后 OME 成年人的变化。 : 36 例（平均年龄 51.4 岁）OME 患者接受为期 3 天的吸入黏液溶解剂和皮质类固醇治疗，通过 AMSA 给药。在干预前后进行鼓室图（鼓室图类型、容积、顺应性、压力和梯度）以测量中耳积液。 : 干预后，29 例（81%）和 14 例（39%）患者分别观察到部分和完全 OME 缓解。受影响耳朵的鼓室图类型在基线和干预后测量之间存在差异（ < 0.001）。分别有 34 例（68%）、1 例（2%）、2 例（4%）和 13 例（26%）受影响的耳朵在鼓室图基础上出现正常化、改善恶化和无变化。干预后，我们观察到连续评估的中耳容积增加（∆ 0.19 毫升， = 0.002）和压力增加（∆ 142 达帕， < 0.001），以及达到顺应性（16%比 54%， < 0.001）和压力（28%比 64%， < 0.001）分类正常化的患者比例更高。 : 年龄、性别或招募季节（均 > 0.05）对治疗效果没有影响。这项初步研究的结果令人鼓舞，但未来的研究仍需要验证 AMSA 在治疗成人 OME 中的应用。
