Department of Laryngology and Laryngological Oncology, Leszek Giec Upper-Silesian Medical Centre of the Silesian Medical University in Katowice, 40-635 Katowice, Poland.
Department of Internal Diseases, Allergology and Clinical Immunology, Medical University of Silesia, 40-752 Katowice, Poland.
Medicina (Kaunas). 2023 Jan 9;59(1):126. doi: 10.3390/medicina59010126.
Background and Objectives: Chronic rhinosinusitis (CRS) is a common disease that can be differentiated into two phenotypes, with or without polyps (CRSwNP) or CRSsNP), which may be unilateral (UNIL) or bilateral (BIL). CRS may have an impact on absolute neutrophils and lymphocytes count in peripheral blood. The aim of the study was to investigate whether the incidence of a specific CRS phenotype changes with age and to compare the values of neutrophils, lymphocytes and neutrophil-to-lymphocyte ratio in the peripheral blood between groups of patients below and above 65 years of age with different CRS phenotypes. Material and Methods: A total of 235 patients aged 65 and over were examined, including 140 (59.6%) males. The group of patients <65 years of age comprised 160 subjects, including 103 (64.4%) males. In both groups, the sequence of frequency of particular phenotypes was similar: the most common phenotype was bilateral CRSwNP followed by CRSsNP BIL, CRSsNP UNIL, and finally, CRSwNP UNIL. Direct comparisons between determined phenotype in both groups of different ages revealed that, in the group ≥65 years, CRSwNP BIL occurred significantly more often than in the group <65 years of age. In fact, in the <65 group, bilateral CRSsNP was more common. The absolute neutrophils and lymphocytes counts were significantly higher in the whole group of patients with CRS ≥65 years of age and absolute number of neutrophils was higher in ≥65 years of age group with bilateral CRSsNP. Conclusions: The higher number of neutrophils in the whole ≥65 years of age group and in older patients with bilateral CRSsNP may indicate that CRS, despite of phenotype, may be an important source of infection that requires surgical treatment in elderly patients as well.
慢性鼻-鼻窦炎（CRS）是一种常见疾病，可分为伴有或不伴息肉（CRSwNP 或 CRSsNP）两种表型，也可能为单侧（UNIL）或双侧（BIL）。CRS 可能会影响外周血中绝对中性粒细胞和淋巴细胞计数。本研究旨在探讨特定 CRS 表型的发生率是否随年龄而变化，并比较不同 CRS 表型的<65 岁和≥65 岁患者组外周血中性粒细胞、淋巴细胞和中性粒细胞与淋巴细胞比值的数值。
共检查了 235 名 65 岁以上的患者，包括 140 名（59.6%）男性。<65 岁的患者组包括 160 名患者，包括 103 名（64.4%）男性。在两组中，特定表型的频率顺序相似：最常见的表型是双侧 CRSwNP，其次是 BIL 的 CRSsNP、UNIL 的 CRSsNP，最后是 UNIL 的 CRSwNP。对两组不同年龄的特定表型进行直接比较后发现，在≥65 岁的组中，双侧 CRSwNP 比<65 岁的组更常见。实际上，在<65 岁组中，双侧 CRSsNP 更为常见。在整个≥65 岁的 CRS 患者组中，绝对中性粒细胞和淋巴细胞计数显著升高，而在双侧 CRSsNP 的≥65 岁组中，绝对中性粒细胞计数更高。
在整个≥65 岁的年龄组以及双侧 CRSsNP 的老年患者中，中性粒细胞数量较高，可能表明 CRS 尽管表型不同，但仍可能是感染的重要来源，因此老年患者也需要手术治疗。
