Oster Yonatan, Abu Ahmad Wiessam, Michael-Gayego Ayelet, Rivkin Mila, Levinzon Leonid, Wolf Dana, Nir-Paz Ran, Elinav Hila
Department of Clinical Microbiology and Infectious Diseases, Hadassah Hebrew University Medical Center, Jerusalem 9112001, Israel.
The Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem 9190401, Israel.
Microorganisms. 2023 Jan 9;11(1):166. doi: 10.3390/microorganisms11010166.
previous worldwide reports indicated a substantial short-term reduction in various respiratory infections during the early phase of the SARS-CoV-2 pandemic.
exploring the long-term impact of the COVID-19 pandemic on respiratory pathogens.
retrospective analysis of bacterial and viral positivity rate in respiratory samples, between 1 January 2017-30 June 2022 in a tertiary hospital in Jerusalem, Israel.
A decline in overall respiratory tests and positivity rate was observed in the first months of the pandemic. Respiratory isolations of and were insignificantly affected and returned to their monthly average by November 2020, despite a parallel surge in COVID-19 activity, while was almost eliminated from the respiratory pathogens scene. Each viral pathogen acted differently, with adenovirus affected only for few months. Human-metapneumovirus and respiratory-syncytial-virus had reduced activity for approximately a year, and influenza A virus resurged in November 2021 with the elimination of Influenza-B.
After an immediate decline in non-SARS-CoV-2 respiratory infections, each pathogen has a different pattern during a 2-year follow-up. These patterns might be influenced by intrinsic factors of each pathogen and different risk reduction behaviors of the population. Since some of these measures will remain in the following years, we cannot predict the timing of return to pre-COVID-19 normalcy.
此前的全球报告显示，在严重急性呼吸综合征冠状病毒2（SARS-CoV-2）大流行的早期阶段，各种呼吸道感染在短期内大幅减少。
探讨2019冠状病毒病（COVID-19）大流行对呼吸道病原体的长期影响。
对以色列耶路撒冷一家三级医院2017年1月1日至2022年6月30日期间呼吸道样本中的细菌和病毒阳性率进行回顾性分析。
在大流行的头几个月，观察到总体呼吸道检测和阳性率下降。肺炎链球菌和金黄色葡萄球菌的呼吸道分离受影响不显著，到2020年11月恢复到月平均水平，尽管COVID-19活动同时激增，而肺炎克雷伯菌几乎从呼吸道病原体中消失。每种病毒病原体的表现各不相同，腺病毒仅在几个月内受到影响。人偏肺病毒和呼吸道合胞病毒的活性降低了约一年，甲型流感病毒在2021年 November随着乙型流感的消失而再次出现。
在非SARS-CoV-2呼吸道感染立即下降后，在2年的随访中，每种病原体都有不同的模式。这些模式可能受每种病原体的内在因素和人群不同的风险降低行为影响。由于其中一些措施将在接下来的几年中持续存在，我们无法预测恢复到COVID-19前正常状态的时间。
