Grupo de Investigación Sobre Nuevos Materiales, Universidad Pontificia Bolivariana, Medellín 050031, Colombia.
Grupo de Investigación e Innovación en Energía, Institución Universitaria Pascual Bravo, Medellín 050036, Colombia.
Molecules. 2023 Jan 6;28(2):589. doi: 10.3390/molecules28020589.
Even though some methods for the detection of colorectal cancer have been used clinically, most of the techniques used do not consider the in situ detection of colorectal cancer (CRC) biomarkers, which would favor in vivo real-time monitoring of the carcinogenesis process and consequent studies of the disease. In order to give a scientific and computational framework ideal for the evaluation of diagnosis techniques based on the early detection of biomarker molecules modeled as spherical particles from the computational point of view, a computational representation of the rectum, stool and biomarker particles was developed. As consequence of the transport of stool, there was a displacement of CRC biomarker particles that entered the system as a result of the cellular apoptosis processes in polyps with a length lower than 1 cm, reaching a maximum velocity of 3.47×10-3 m/s. The biomarkers studied showed trajectories distant to regions of the polyp of origin in 1 min of simulation. The research results show that the biomarker particles for CRC respond to the variations in the movements of the stool with trajectories and speeds that depend on the location of the injury, which will allow locating the regions with the highest possibilities of catching particles through in situ measurement instruments in the future.
尽管已经有一些用于检测结直肠癌的方法在临床上得到了应用，但大多数使用的技术都没有考虑到结直肠癌（CRC）生物标志物的原位检测，这将有利于对致癌过程进行体内实时监测，并对该疾病进行相应的研究。为了从计算的角度为基于生物标志物分子早期检测的诊断技术的评估提供一个理想的科学和计算框架，我们开发了一种对直肠、粪便和生物标志物颗粒的计算表示。由于粪便的传输，CRC 生物标志物颗粒发生了位移，这些颗粒是由于长度小于 1 厘米的息肉中的细胞凋亡过程而进入系统的，达到了 3.47×10-3 m/s 的最大速度。在模拟的 1 分钟内，研究的生物标志物显示出与息肉起源区域有较远的轨迹。研究结果表明，CRC 的生物标志物颗粒对粪便运动的变化有响应，其轨迹和速度取决于损伤的位置，这将允许通过未来的原位测量仪器定位到捕获颗粒的可能性最高的区域。
