Gold C H, Viljoen M
S Afr Med J. 1978 Sep 30;54(14):569-71.
Xipamide (4-chloro-5-sulphamyl-salicylic acid 2', 6'-dimethylanilide) is a diuretic and antihypertensive agent. A clinical trial of the drug was performed in 11 patients, 8 with nephrotic syndrome, 1 with oedema and ascites due to hepatic cirrhosis, and 2 with congestive cardiac failure due to idiopathic cardiomyopathy. The drug proved to be potent, safe and efficacious. Side-effects were similar to those encountered with other thiazide-derived diuretics, but were not of a severe nature. Wider clinical usage of xipamide would appear to be warranted.
氯磺水杨胺（4-氯-5-氨磺酰基水杨酸2'，6'-二甲基苯胺）是一种利尿剂和抗高血压药。对11例患者进行了该药物的临床试验，其中8例患有肾病综合征，1例因肝硬化导致水肿和腹水，2例因特发性心肌病导致充血性心力衰竭。该药物被证明有效、安全且高效。副作用与其他噻嗪类利尿剂相似，但并不严重。氯磺水杨胺似乎有必要进行更广泛的临床应用。
