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用于寨卡病毒/登革热病毒分子诊断的DNA纳米技术驱动的生物传感器的最新进展

Recent Developments in DNA-Nanotechnology-Powered Biosensors for Zika/Dengue Virus Molecular Diagnostics.

作者信息

Park Goeun, Park Hanbin, Park Sang-Chan, Jang Moonbong, Yoon Jinho, Ahn Jae-Hyuk, Lee Taek

机构信息

Department of Chemical Engineering, Kwangwoon University, Seoul 01897, Republic of Korea.

Department of Electronics Engineering, Chungnam National University, 99 Daehak-ro, Yuseong-gu, Daejeon 34134, Republic of Korea.

出版信息

Nanomaterials (Basel). 2023 Jan 16;13(2):361. doi: 10.3390/nano13020361.

DOI:10.3390/nano13020361
PMID:36678114
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9864780/
Abstract

Zika virus (ZIKV) and dengue virus (DENV) are highly contagious and lethal mosquito-borne viruses. Global warming is steadily increasing the probability of ZIKV and DENV infection, and accurate diagnosis is required to control viral infections worldwide. Recently, research on biosensors for the accurate diagnosis of ZIKV and DENV has been actively conducted. Moreover, biosensor research using DNA nanotechnology is also increasing, and has many advantages compared to the existing diagnostic methods, such as polymerase chain reaction (PCR) and enzyme-linked immunosorbent assay (ELISA). As a bioreceptor, DNA can easily introduce a functional group at the 5' or 3' end, and can also be used as a folded structure, such as a DNA aptamer and DNAzyme. Instead of using ZIKV and DENV antibodies, a bioreceptor that specifically binds to viral proteins or nucleic acids has been fabricated and introduced using DNA nanotechnology. Technologies for detecting ZIKV and DENV can be broadly divided into electrochemical, electrical, and optical. In this review, advances in DNA-nanotechnology-based ZIKV and DENV detection biosensors are discussed.

摘要

寨卡病毒（ZIKV）和登革热病毒（DENV）是极具传染性和致命性的蚊媒病毒。全球变暖正稳步增加寨卡病毒和登革热病毒感染的可能性，因此需要准确诊断以控制全球范围内的病毒感染。最近，针对寨卡病毒和登革热病毒准确诊断的生物传感器研究正在积极开展。此外，利用DNA纳米技术的生物传感器研究也在增加，与现有的诊断方法（如聚合酶链反应（PCR）和酶联免疫吸附测定（ELISA））相比具有许多优势。作为生物受体，DNA可以很容易地在5'或3'末端引入官能团，也可以用作折叠结构，如DNA适配体和DNA酶。利用DNA纳米技术制备并引入了一种能与病毒蛋白或核酸特异性结合的生物受体，而不是使用寨卡病毒和登革热病毒抗体。检测寨卡病毒和登革热病毒的技术大致可分为电化学、电学和光学技术。在这篇综述中，将讨论基于DNA纳米技术的寨卡病毒和登革热病毒检测生物传感器的进展。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fef/9864780/7005e6483b0a/nanomaterials-13-00361-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fef/9864780/2c3ff7b5f744/nanomaterials-13-00361-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fef/9864780/cd796c081478/nanomaterials-13-00361-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fef/9864780/f4b220f02590/nanomaterials-13-00361-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fef/9864780/d949d62d7a8a/nanomaterials-13-00361-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fef/9864780/8c3074b1b524/nanomaterials-13-00361-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fef/9864780/76d14513380c/nanomaterials-13-00361-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fef/9864780/7005e6483b0a/nanomaterials-13-00361-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fef/9864780/2c3ff7b5f744/nanomaterials-13-00361-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fef/9864780/cd796c081478/nanomaterials-13-00361-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fef/9864780/f4b220f02590/nanomaterials-13-00361-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fef/9864780/d949d62d7a8a/nanomaterials-13-00361-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fef/9864780/8c3074b1b524/nanomaterials-13-00361-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fef/9864780/76d14513380c/nanomaterials-13-00361-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8fef/9864780/7005e6483b0a/nanomaterials-13-00361-g006.jpg

相似文献

[1]
Recent Developments in DNA-Nanotechnology-Powered Biosensors for Zika/Dengue Virus Molecular Diagnostics.

Nanomaterials (Basel). 2023-1-16

[2]
Molecular and serological techniques to detect co-circulation of DENV, ZIKV and CHIKV in suspected dengue-like syndrome patients.

J Clin Virol. 2016-9

[3]
One-step pentaplex real-time polymerase chain reaction assay for detection of zika, dengue, chikungunya, West nile viruses and a human housekeeping gene.

J Clin Virol. 2019-9-16

[4]
Validation of serological and molecular methods for diagnosis of zika virus infections.

J Virol Methods. 2018-10-18

[5]
Combination of Nonstructural Protein 1-Based Enzyme-Linked Immunosorbent Assays Can Detect and Distinguish Various Dengue Virus and Zika Virus Infections.

J Clin Microbiol. 2019-1-30

[6]
Dengue and Zika virus infections in children elicit cross-reactive protective and enhancing antibodies that persist long term.

Sci Transl Med. 2021-10-6

[7]
Serological tests reveal significant cross-reactive human antibody responses to Zika and Dengue viruses in the Mexican population.

Acta Trop. 2019-9-25

[8]
In-depth molecular analysis of a small cohort of human and Aedes mosquito (adults and larvae) samples from Kolkata revealed absence of Zika but high prevalence of dengue virus.

J Med Microbiol. 2018-6-13

[9]
Comprehensive Evaluation of Differential Serodiagnosis between Zika and Dengue Viral Infections.

J Clin Microbiol. 2019-2-27

[10]
Re-evaluation of routine dengue virus serology in travelers in the era of Zika virus emergence.

J Clin Virol. 2017-5-3

引用本文的文献

[1]
Portable Point-of-Care Diagnosis Platforms and Emerging Predictive Biomarkers for Rapid Detection of Severe Dengue Viral Infection.

ACS Sens. 2025-5-23

[2]
A one-pot method for universal Dengue virus detection by combining RT-RPA amplification and CRISPR/Cas12a assay.

BMC Microbiol. 2025-3-25

[3]
Biosensors for the detection of flaviviruses: A review.

Synth Syst Biotechnol. 2024-10-26

[4]
Advancing Topoisomerase Research Using DNA Nanotechnology.

Small Methods. 2025-6

[5]
Structural DNA nanotechnology at the nexus of next-generation bio-applications: challenges and perspectives.

Nanoscale Adv. 2023-12-19

[6]
Current research status of tumor cell biomarker detection.

Microsyst Nanoeng. 2023-10-5

[7]
Biosensing Systems Based on Graphene Oxide Fluorescence Quenching Effect.

Micromachines (Basel). 2023-7-28

本文引用的文献

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The detection and identification of dengue virus serotypes with quantum dot and AuNP regulated localized surface plasmon resonance.

Nanoscale Adv. 2019-12-13

[2]
DNA aptamer selection and construction of an aptasensor based on graphene FETs for Zika virus NS1 protein detection.

Beilstein J Nanotechnol. 2022-9-2

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Nano Converg. 2022-9-10

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Bone Res. 2022-5-23

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Electrochemical biosensor with aptamer/porous platinum nanoparticle on round-type micro-gap electrode for saxitoxin detection in fresh water.

Biosens Bioelectron. 2022-8-15

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Sensors (Basel). 2021-12-20

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Improving Biosensors by the Use of Different Nanomaterials: Case Study with Microcystins as Target Analytes.

Biosensors (Basel). 2021-12-20

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