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基于聚己内酯的精油及其纳米制剂的化学特征研究及其抗真菌活性研究。 （原文中“against of”表述有误，正确应为“against”）

Study of the Chemical Profile and Anti-Fungal Activity against of Essential Oil and of Its Nano-Formulations Based on Polycaprolactone.

作者信息

Rosato Roberto, Napoli Edoardo, Granata Giuseppe, Di Vito Maura, Garzoli Stefania, Geraci Corrada, Rizzo Silvia, Torelli Riccardo, Sanguinetti Maurizio, Bugli Francesca

机构信息

Dipartimento di Scienze Biotecnologiche di Base, Cliniche Intensivologiche e Perioperatorie, Università Cattolica del Sacro Cuore, 00167 Rome, Italy.

Istituto di Chimica Biomolecolare-Consiglio Nazionale delle Ricerche, 95126 Catania, Italy.

出版信息

Plants (Basel). 2023 Jan 12;12(2):358. doi: 10.3390/plants12020358.

DOI:10.3390/plants12020358
PMID:36679069
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9860731/
Abstract

BACKGROUND

represents an emerging pathogen that results in nosocomial infections and is considered a serious global health problem. The aim of this work was to evaluate the in vitro antifungal efficacy of essential oil (CC-EO) pure or formulated in polycaprolactone (PCL) nanoparticles against ten clinical strains of .

METHODS

nanoparticles of PCL were produced using CC-EO (nano-CC-EO) and cinnamaldehyde (CIN) through the nanoprecipitation method. The chemical profile of both CC-EO and nano-CC-EO was evaluated using SPME sampling followed by GC-MS analysis. Micro-broth dilution tests were performed to evaluate both fungistatic and fungicidal effectiveness of CC-EO and CIN, pure and nano-formulated. Furthermore, checkerboard tests to evaluate the synergistic action of CC-EO or nano-CC-EO with micafungin or fluconazole were conducted. Finally, the biofilm disrupting activity of both formulations was evaluated.

RESULTS

GC-MS analysis shows a different composition between CC-EO and nano-CC-EO. Moreover, the microbiological analyses do not show any variation in antifungal effectiveness either towards the planktonic form (MIC = 0.01 ± 0.01 and MIC = 0.02 ± 0.01) or the biofilm form. No synergistic activity with the antifungal drugs tested was found.

CONCLUSIONS

both CC-EO and nano-CC-EO show the same antimicrobial effectiveness and are potential assets in the fight against

摘要

背景

是一种新兴病原体，可导致医院感染，被视为严重的全球健康问题。本研究的目的是评估纯的或聚己内酯（PCL）纳米颗粒制剂形式的精油（CC-EO）对十种临床菌株的体外抗真菌效果。

方法

通过纳米沉淀法使用CC-EO（纳米CC-EO）和肉桂醛（CIN）制备PCL纳米颗粒。使用固相微萃取采样随后进行气相色谱-质谱分析来评估CC-EO和纳米CC-EO的化学特征。进行微量肉汤稀释试验以评估CC-EO和CIN纯品及纳米制剂形式的抑菌和杀菌效果。此外，进行棋盘试验以评估CC-EO或纳米CC-EO与米卡芬净或氟康唑的协同作用。最后，评估两种制剂的生物膜破坏活性。

结果

气相色谱-质谱分析显示CC-EO和纳米CC-EO之间的组成不同。此外，微生物学分析表明，无论是对浮游形式（MIC = 0.01±0.01和MIC = 0.02±0.01）还是生物膜形式，抗真菌效果均无任何差异。未发现与所测试的抗真菌药物有协同活性。

结论

CC-EO和纳米CC-EO均显示出相同的抗菌效果，是对抗……的潜在有效物质

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d825/9860731/9c3b45e17617/plants-12-00358-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d825/9860731/9c3b45e17617/plants-12-00358-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d825/9860731/9c3b45e17617/plants-12-00358-g001.jpg

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