Asad Mohammad, Arshad Muhammad Nadeem, Asiri Abdullah M, Rahman Mohammed M, Kumaran Snigdha, Thorakkattil Neerankuzhiyil Mohammed Musthafa
Chemistry Department, Faculty of Science, King Abdulaziz University, P.O. Box 80203, Jeddauh 21589, Saudi Arabia.
Center of Excellence for Advanced Materials Research (CEAMR), King Abdulaziz University, P.O. Box 80203, Jeddah 21589, Saudi Arabia.
Polymers (Basel). 2023 Jan 13;15(2):429. doi: 10.3390/polym15020429.
Chitosan-bounded copper (chitosan-Cu) was introduced for green synthesis of novel ferrocenated spiropyrrolidine hybrids, namely 3'-(4-.bromobenzoyl)-5'-(4-hydroxybenzyl)-4'-ferrocenylspiro[indoline-3,2'-pyrrolidin]-2-one and 3'-(4-bromobenzoyl)-4'-ferrocenylspiro[indoline-3,2'-pyrrolidin]-2-one, in good yield. A one-pot three-component 1,3-dipolar cycloaddition reaction was employed for the formation of spiropyrrolidines from 1-(4-bromophenyl)-ferrocene-prop-2-en-1-one and azomethine ylides, which were developed in situ from tyrosine, glycine, and isatin, respectively. Various spectroscopic methods were used to establish the structures of spiropyrrolidines, and a single crystal X-ray diffraction study of a spiropyrrolidine provided additional confirmation. The crystallographic study revealed that compound has one independent molecule in its unit cell, which is correlated with Hirshfeld surface analysis, and describes intramolecular contacts adversely. The highly yielded products in green conditions were determined for their antibacterial significance and were found to have good activity against Gram-positive and Gram-negative bacterial strains.
引入壳聚糖结合铜（壳聚糖 - 铜）用于绿色合成新型二茂铁基螺吡咯烷杂化物，即3'-（4-溴苯甲酰基）-5'-（4-羟基苄基）-4'-二茂铁基螺[吲哚啉 - 3,2'-吡咯烷] -2-酮和3'-（4-溴苯甲酰基）-4'-二茂铁基螺[吲哚啉 - 3,2'-吡咯烷] -2-酮，产率良好。采用一锅三组分1,3 - 偶极环加成反应，由1 - （4 - 溴苯基） - 二茂铁 - 丙 - 2 - 烯 - 1 - 酮与分别由酪氨酸、甘氨酸和异吲哚酮原位生成的甲亚胺叶立德形成螺吡咯烷。使用各种光谱方法确定螺吡咯烷的结构，对一种螺吡咯烷进行的单晶X射线衍射研究提供了进一步的证实。晶体学研究表明，化合物在其晶胞中有一个独立分子，这与 Hirshfeld 表面分析相关，并对分子内接触进行了不利描述。在绿色条件下高产率得到的产物测定了其抗菌意义，发现对革兰氏阳性和革兰氏阴性细菌菌株具有良好活性。
