通过1,3-偶极环加成反应简便合成色烯并[3,4-c]螺吡咯烷茚并喹喔啉类化合物。
A facile synthesis of chromeno[3,4-c]spiropyrrolidine indenoquinoxalines via 1,3-dipolar cycloadditions.
作者信息
Rahimi Shahnaz, Ghandi Mehdi, Fallahnezhad Maryam, Abbasi Alireza
机构信息
School of Chemistry, College of Science, University of Tehran, P.O. Box 14155 6455, Tehran, Iran.
出版信息
Mol Divers. 2024 Feb;28(1):133-142. doi: 10.1007/s11030-023-10629-3. Epub 2023 Mar 21.
A one-pot, four-component reaction for the synthesis of novel chromeno[3,4-c]spiropyrrolidine-indenoquinoxalines is described via a 1,3-dipolar cycloaddition of 3-acetyl-coumarins with the azomethine ylides followed by deacetylation and protonation (deuteration). The products were obtained in moderate to high yields, and their structures were confirmed by H NMR, C NMR, FT-IR, and MS spectroscopy.
本文描述了一种一锅四组分反应，通过3-乙酰基香豆素与甲亚胺叶立德的1,3-偶极环加成反应，随后进行脱乙酰化和质子化（氘化）反应，合成新型色烯并[3,4-c]螺吡咯烷-茚并喹喔啉。产物以中等至高产率获得，其结构通过氢核磁共振、碳核磁共振、傅里叶变换红外光谱和质谱进行了确证。
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