Institute of Zoonosis, College of Public Health, Zunyi Medical University, Zunyi 563000, China.
Southwest Guizhou Vocational & Technical College Nationalities, Southwest Guizhou Autonomous Prefecture, Xingyi 562400, China.
Viruses. 2023 Jan 5;15(1):165. doi: 10.3390/v15010165.
A new HP-PRRSV strain (SD2020) was isolated from pigs with suspected highly pathogenic porcine reproductive and respiratory syndrome disease in a pig farm in Shandong Province, China, and its genome was sequenced. This pig farm has been using the VR-2332 vaccine strain to immunize pigs for a long time. The phylogenic and single nucleotide polymorphisms (SNPs) analysis of the viruses isolated from dead pigs showed that SD2020 was a natural recombinant virus of the VR-2332 vaccine strain and the JXA1 similar strain, and that two splicing fragments highly homologous to JXA1 in the virus genome were probably derived from the JXA1 wild strain and JXA1-R vaccine strain, respectively. Therefore, the possible recombination events of SD2020 and its mutation site might be related to high pathogenicity.
从中国山东省的一个猪场中疑似感染高致病性猪繁殖与呼吸综合征的病猪中分离到一株新型 HP-PRRSV 毒株（SD2020），并对其基因组进行了测序。该猪场长期使用 VR-2332 疫苗株对猪进行免疫。对病死猪中分离到的病毒进行系统进化和单核苷酸多态性（SNPs）分析表明，SD2020 是 VR-2332 疫苗株与 JXA1 类似株的自然重组病毒，病毒基因组中与 JXA1 高度同源的两个拼接片段可能分别来源于 JXA1 野毒株和 JXA1-R 疫苗株。因此，SD2020 的可能重组事件及其突变位点可能与高致病性有关。
