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猪繁殖与呼吸综合征病毒NSP7蛋白的研究进展

Research Progress on Porcine Reproductive and Respiratory Syndrome Virus NSP7 Protein.

作者信息

Li Huawei, Luo Qin, Jing Huiyuan, Song Yuzhen, Kong Weili, Zhao Mengmeng, Zhu Qingge

机构信息

College of Food and Bioengineering, Henan University of Animal Husbandry and Economy, Zhengzhou 450047, China.

Department of Veterinary Medicine, School of Life Science and Engineering, Foshan University, Foshan 528000, China.

出版信息

Animals (Basel). 2023 Jul 11;13(14):2269. doi: 10.3390/ani13142269.

DOI:10.3390/ani13142269
PMID:37508047
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10376100/
Abstract

Porcine reproductive and respiratory syndrome (PRRS) is a highly contagious and severe infectious disease caused by the PRRS virus (PRRSV). PRRS is characterized by reproductive disorders in sows and respiratory dysfunction in pigs. Non-structural protein 7 (NSP7) is one of the most conserved functional proteins in PRRSV, and it plays an important role in viral replication and humoral immune responses in infected hosts. This review discusses the biological characteristics of NSP7 to provide theoretical support for its application in PRRS diagnosis, novel vaccine design, and therapeutic drug development.

摘要

猪繁殖与呼吸综合征（PRRS）是由猪繁殖与呼吸综合征病毒（PRRSV）引起的一种高度传染性和严重的传染病。PRRS的特征是母猪繁殖障碍和猪的呼吸功能障碍。非结构蛋白7（NSP7）是PRRSV中最保守的功能蛋白之一，它在病毒复制和感染宿主的体液免疫反应中起重要作用。本文综述了NSP7的生物学特性，为其在PRRS诊断、新型疫苗设计和治疗药物开发中的应用提供理论支持。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b888/10376100/2f23e8b71182/animals-13-02269-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b888/10376100/2f23e8b71182/animals-13-02269-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b888/10376100/2f23e8b71182/animals-13-02269-g001.jpg

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Epidemiological investigation and genetic evolutionary analysis of PRRSV-1 on a pig farm in China.中国某猪场猪繁殖与呼吸综合征病毒1型的流行病学调查及遗传进化分析
Front Microbiol. 2022 Dec 1;13:1067173. doi: 10.3389/fmicb.2022.1067173. eCollection 2022.
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Characterization and Pathogenicity of Two Novel PRRSVs Recombined by NADC30-like and NADC34-like Strains in China.
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Viruses. 2022 Sep 30;14(10):2174. doi: 10.3390/v14102174.
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Evolution Characterization and Pathogenicity of a Porcine Reproductive and Respiratory Syndrome Virus Isolate from a Pig Farm in Shandong Province, China.中国山东省某猪场猪繁殖与呼吸综合征病毒分离株的进化特征与致病性分析。
Viruses. 2022 May 31;14(6):1194. doi: 10.3390/v14061194.
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