Bernhard-Nocht Institute for Tropical Medicine, 20359 Hamburg, Germany.
German Center for Infection Research, Partner Site Hamburg-Borstel-Lübeck, 38124 Braunschweig, Germany.
Viruses. 2023 Jan 13;15(1):228. doi: 10.3390/v15010228.
Different humanized mouse models have been developed to study human diseases such as autoimmune illnesses, cancer and viral infections. These models are based on the use of immunodeficient mouse strains that are transplanted with human tissues or human immune cells. Among the latter, mice transplanted with hematopoietic stem cells have been widely used to study human infectious diseases. However, mouse models built upon the transplantation of donor-specific mature immune cells are still under development, especially in the field of viral infections. These models can retain the unique immune memory of the donor, making them suitable for the study of correlates of protection upon natural infection or vaccination. Here, we will review some of these models and how they have been applied to virology research. Moreover, the future applications and the potential of these models to design therapies against human viral infections are discussed.
已经开发了不同的人源化小鼠模型来研究人类疾病，如自身免疫性疾病、癌症和病毒感染。这些模型基于使用免疫缺陷小鼠品系，这些小鼠品系移植了人类组织或人类免疫细胞。在后者中，移植了造血干细胞的小鼠被广泛用于研究人类传染病。然而，基于供体特异性成熟免疫细胞移植的小鼠模型仍在开发中，特别是在病毒感染领域。这些模型可以保留供体独特的免疫记忆，使其适合于研究自然感染或接种疫苗后的保护相关性。在这里，我们将回顾其中的一些模型，以及它们如何被应用于病毒学研究。此外，还讨论了这些模型的未来应用及其设计针对人类病毒感染的治疗方法的潜力。
