Departamento de Ciencia y Tecnología, Universidad Nacional de Quilmes, Bernal, Argentina.
European Institute for the Biology of Aging, University Medical Center Groningen, Groningen, the Netherlands.
J Biol Rhythms. 2023 Apr;38(2):131-147. doi: 10.1177/07487304221143483. Epub 2023 Jan 21.
Circadian rhythms represent an adaptive feature, ubiquitously found in nature, which grants living beings the ability to anticipate daily variations in their environment. They have been found in a multitude of organisms, ranging from bacteria to fungi, plants, and animals. Circadian rhythms are generated by endogenous clocks that can be entrained daily by environmental cycles such as light and temperature. The molecular machinery of circadian clocks includes a transcriptional-translational feedback loop that takes approximately 24 h to complete. has been a model organism of choice to understand the molecular basis of circadian clocks. However, alternative animal models are also being adopted, each offering their respective experimental advantages. The nematode provides an excellent model for genetics and neuro-behavioral studies, which thanks to its ease of use and manipulation, as well as availability of genetic data and mutant strains, is currently used as a novel model for circadian research. Here, we aim to evaluate as a model for chronobiological studies, focusing on its strengths and weaknesses while reviewing the available literature. Possible zeitgebers (including light and temperature) are also discussed. Determining the molecular bases and the neural circuitry involved in the central pacemaker of the ' clock will contribute to the understanding of its circadian system, becoming a novel model organism for the study of diseases due to alterations of the circadian cycle.
昼夜节律是一种适应性特征，普遍存在于自然界中，使生物能够预测环境的日常变化。它存在于从细菌到真菌、植物和动物等多种生物中。昼夜节律是由内源性时钟产生的，可以通过环境周期（如光和温度）每天进行调整。昼夜节律的分子机制包括一个转录翻译反馈回路，大约需要 24 小时才能完成。 已成为理解昼夜节律分子基础的首选模式生物。然而，也在采用替代的动物模型，每个模型都提供了各自的实验优势。线虫 提供了用于遗传学和神经行为研究的极好模型，由于其易于使用和操作，以及遗传数据和突变株的可用性，它目前被用作昼夜节律研究的新型模型。在这里，我们旨在评估 作为生物钟研究的模型，重点讨论其优缺点，同时回顾现有文献。还讨论了可能的授时因子（包括光和温度）。确定“时钟”中央起搏器所涉及的分子基础和神经回路将有助于理解其昼夜节律系统，并成为研究由于昼夜节律周期改变而导致的疾病的新型模式生物。
