Department of Rheumatology and Immunology, the First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China; College of Medicine and Health, Lishui University, No. 1 Xueyuan Road, Liandu District, Lishui 323000, China.
Department of Rheumatology and Immunology, the First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China.
J Adv Res. 2023 Dec;54:181-193. doi: 10.1016/j.jare.2023.01.012. Epub 2023 Jan 18.
Innate and adaptive immunity are two different parts of the immune system that have different characteristics and work together to provide immune protection. Inflammasomes are a major part of the innate immune system that are expressed widely in myeloid cells and are responsible for inflammatory responses. Recent studies have shown that inflammasomes are also expressed and activated in lymphocytes, especially in T and B cells, to regulate the adaptive immune response. Activation of inflammasomes is also under the control of lymphocytes. Therefore, we propose that inflammasomes act as a bridge and they provide crosstalk between the innate and adaptive immune systems to obtain a fine balance in immune responses.
This review systematially summarizes the interaction between inflammasomes and lymphocytes and describes the crosstalk between the innate and adaptive immune systems induced by inflammasomes, with the aim of providing new directions and important areas for further research.
When considering the novel function of inflammasomes in various lymphocytes, attention should be given to the activity of specific inflammasomes in studies of lymphocyte function. Moreover, research on the function of various inflammasomes in lymphocytes will help advance knowledge on the mechanisms and treatment of various diseases, including autoimmune diseases and tumors. In addition, when studying inflammatory responses, inflammasomes in both lymphocytes and myeloid cells need to be considered.
先天免疫和适应性免疫是免疫系统的两个不同部分，具有不同的特征，共同提供免疫保护。炎性体是先天免疫系统的一个主要组成部分，广泛表达于髓样细胞中，负责炎症反应。最近的研究表明，炎性体也在淋巴细胞中表达和激活，特别是在 T 和 B 细胞中，以调节适应性免疫反应。炎性体的激活也受到淋巴细胞的控制。因此，我们提出炎性体作为桥梁，它们在先天免疫和适应性免疫系统之间提供串扰，以获得免疫反应的精细平衡。
本综述系统总结了炎性体与淋巴细胞之间的相互作用，并描述了炎性体诱导的先天免疫和适应性免疫系统之间的串扰，旨在为进一步研究提供新的方向和重要领域。
在考虑炎性体在各种淋巴细胞中的新功能时，应注意研究淋巴细胞功能时特定炎性体的活性。此外，研究各种炎性体在淋巴细胞中的功能将有助于推进各种疾病（包括自身免疫性疾病和肿瘤）的机制和治疗的知识。另外，在研究炎症反应时，需要同时考虑淋巴细胞和髓样细胞中的炎性体。
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