Najman Jake M, Bell Scott, Williams Gail M, Clavarino Alexandra M, Scott James G, McGee Tara R, Mamun Abdullah A
School of Public Health, Faculty of Medicine, The University of Queensland, 266 Herston Road, Herston, Qld, 4006, Australia.
Children's Health Research Centre, Faculty of Medicine, University of Queensland, Graham Road, South Brisbane, Qld, 4101, Australia.
Respir Med. 2023 Mar;208:107124. doi: 10.1016/j.rmed.2023.107124. Epub 2023 Jan 19.
Use of tobacco and cannabis is common and has been reported to predict lung function. Less is known about co-use of tobacco and cannabis and their impact on changes in lung function to early adulthood.
The study examines whether cigarette smoking or cannabis use and co-use are each associated with lung function in a population sample of young adults.
Data are from a prospective cohort study of cigarette smoking, cannabis use and co-use at 21 and 30 years of age and lung function (FVC, FEV, FEV/FVC) measured at 30 years. Lung function results are transformed using Global Lung Function Formulae. Subjects are the children of pregnant women who were recruited into the cohort study over the period 1981-3. Respondents were administered a spirometry assessment at 21 and 30 years of age. These respondents completed a smoking and cannabis use questionnaire at 21- and 30-year follow-ups.
Cigarette smoking (with or without cannabis use) is associated with reduced airflow. There is no consistent association between cannabis use and measures of lung function. The co-use of tobacco and cannabis appears to entail no additional risk to lung function beyond the risks associated with tobacco use alone.
Persistent cigarette smoking is associated with reduced airflow even in young adults. Cannabis use does not appear to be related to lung function even after years of use.
烟草和大麻的使用很常见，据报道可预测肺功能。对于烟草和大麻的共同使用及其对成年早期肺功能变化的影响，人们了解较少。
该研究调查在年轻成年人的人群样本中，吸烟、使用大麻以及两者共同使用是否分别与肺功能相关。
数据来自一项前瞻性队列研究，涉及21岁和30岁时的吸烟、大麻使用及共同使用情况，以及30岁时测量的肺功能（用力肺活量（FVC）、第一秒用力呼气容积（FEV）、FEV/FVC）。肺功能结果使用全球肺功能公式进行转换。研究对象是1981 - 1983年期间被纳入队列研究的孕妇的子女。受访者在21岁和30岁时接受了肺活量测定评估。这些受访者在21年和30年随访时完成了吸烟和大麻使用问卷调查。
吸烟（无论是否使用大麻）与气流减少有关。大麻使用与肺功能指标之间没有一致的关联。烟草和大麻共同使用似乎除了单独使用烟草相关的风险外，不会给肺功能带来额外风险。
持续吸烟即使在年轻成年人中也与气流减少有关。即使经过多年使用，大麻使用似乎与肺功能无关。
