Al-Saidan S M, Selkirk A B, Winfield A J
School of Pharmacy, Robert Gordon's Institute of Technology, Aberdeen, Scotland, U.K.
J Invest Dermatol. 1987 Oct;89(4):426-9. doi: 10.1111/1523-1747.ep12471784.
The effect of dimethylsulfoxide (DMSO) concentration on the permeability of neonatal rat stratum corneum to 14C labeled propan-1-ol and hexan-1-ol was studied in vitro. The permeability coefficients were determined from a range of DMSO-water systems. After soaking in water overnight, the same stratum corneum was used with water as both delivery and recipient phases for the alkanols. Concentrations below 70% DMSO reduced the penetration rate as a result of the solvent effect of DMSO and the formation of a DMSO-alkanol complex. Above 70% DMSO permeability increased, with a permeability coefficient greater than that from water being achieved at concentrations in excess of 80% DMSO. The second run, with water as delivery phase, showed that the effect was reversible below 70% DMSO, but that at higher concentrations DMSO had produced an irreversible change in the permeability of stratum corneum. We hypothesize a hydrogen bond-mediated mechanism for the increased permeability.
体外研究了二甲基亚砜（DMSO）浓度对新生大鼠角质层对14C标记的丙醇和己醇渗透性的影响。渗透性系数由一系列DMSO - 水体系测定。过夜浸泡在水中后，将相同的角质层用于醇类的传递相和接受相均为水的情况。低于70% DMSO的浓度由于DMSO的溶剂效应和DMSO - 醇络合物的形成而降低了渗透速率。高于70% DMSO时渗透性增加，在超过80% DMSO的浓度下实现了大于水的渗透性系数。第二次实验，以水为传递相，结果表明在70% DMSO以下该效应是可逆的，但在较高浓度下DMSO对角质层的渗透性产生了不可逆的变化。我们推测渗透性增加是由氢键介导的机制引起的。
