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偏头痛患者的静息-活动节律变化与焦虑症状有关。

Changes in the rest-activity rhythm in migraine patients are associated with anxiety symptoms.

机构信息

Programa de Pós-Graduação em Neuropsiquiatria e Ciências do Comportamento (Posneuro), Universidade Federal de Pernambuco (UFPE), Recife, PE, Brazil.

Departamento de Fisioterapia, Universidade Estadual da Paraíba (UEPB), Campina Grande, PB, Brazil.

出版信息

Braz J Psychiatry. 2022 Oct 7;44(6):611-620. doi: 10.47626/1516-4446-2021-2367.

DOI:10.47626/1516-4446-2021-2367
PMID:36683002
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9851770/
Abstract

OBJECTIVE

To characterize rest-activity rhythm in chronic migraine (CM) and to investigate the relationship between this rhythm and depressive and anxiety symptoms in patients with CM.

METHODS

This was a study of adults aged 20 to 40 years. The rest-activity rhythm of patients with CM (n=23) and non-headache controls (NH, n=23) was assessed by actigraphy for 15 days, and they completed the following assessments: Visual Analogue Scale for pain intensity; Headache Diary; Headache Impact Test-6; Morningness-Eveningness Questionnaire; Pittsburgh Sleep Quality Index; Epworth Sleepiness Scale; Beck Depression Inventory; and State-Trait Anxiety Inventory.

RESULTS

Patients with CM showed less activity over 24 hours and more fragmented sleep. Reduced interdaily stability of the rest-activity rhythm was observed, with less robustness of this rhythm in the CM group. Multiple linear regressions revealed a significant association between the rest-activity rhythm and trait anxiety variables in patients with CM, specifically regarding the relative amplitude of the cycle, activity throughout 24 hours and during sleep, and robustness of the rest-activity rhythm.

CONCLUSIONS

Our findings provide evidence that the robustness of the rest-activity rhythm, activity throughout 24 hours, and sleep fragmentation are associated with trait anxiety in patients with CM.

摘要

目的

描述慢性偏头痛（CM）患者的静息-活动节律，并探讨该节律与 CM 患者抑郁和焦虑症状之间的关系。

方法

这是一项针对 20 至 40 岁成年人的研究。通过活动记录仪评估 CM 患者（n=23）和非头痛对照者（NH，n=23）的静息-活动节律，他们完成了以下评估：疼痛强度视觉模拟量表；头痛日记；头痛影响测试-6；晨暮倾向问卷；匹兹堡睡眠质量指数；爱泼沃斯嗜睡量表；贝克抑郁量表；状态-特质焦虑量表。

结果

CM 患者 24 小时内的活动量较少，睡眠碎片化较多。观察到静息-活动节律的日间稳定性降低，CM 组的节律稳定性较差。多元线性回归显示，CM 患者的静息-活动节律与特质焦虑变量之间存在显著关联，具体涉及周期的相对幅度、24 小时内的活动量以及睡眠期间的活动量和静息-活动节律的稳定性。

结论

我们的研究结果提供了证据，表明静息-活动节律的稳定性、24 小时内的活动量和睡眠碎片化与 CM 患者的特质焦虑有关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/47b3/9851770/ca249e98ea05/bjp-44-06-611-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/47b3/9851770/65f1338b4290/bjp-44-06-611-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/47b3/9851770/ca249e98ea05/bjp-44-06-611-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/47b3/9851770/65f1338b4290/bjp-44-06-611-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/47b3/9851770/ca249e98ea05/bjp-44-06-611-g002.jpg

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