Department of Neurology, Renmin Hospital of Wuhan University, Wuhan, Hubei, China.
Department of Neurology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Aging Dis. 2024 Aug 1;15(4):1565-1587. doi: 10.14336/AD.2023.0921.
Intrinsic biological clocks drive the circadian rhythm, which coordinates the physiological and pathophysiological processes in the body. Recently, a bidirectional relationship between circadian rhythms and several neurological diseases has been reported. Neurological diseases can lead to the disruption of circadian homeostasis, thereby increasing disease severity. Therefore, optimizing the current treatments through circadian-based approaches, including adjusted dosing, changing lifestyle, and targeted interventions, offer a promising opportunity for better clinical outcomes and precision medicine. In this review, we provide detailed implications of the circadian rhythm in neurological diseases through bench-to-bedside approaches. Furthermore, based on the unsatisfactory clinical outcomes, we critically discuss the potential of circadian-based interventions, which may encourage more studies in this discipline, with the hope of improving treatment efficacy in neurological diseases.
内在生物钟驱动着昼夜节律，协调着体内的生理和病理生理过程。最近，有报道称昼夜节律与几种神经疾病之间存在双向关系。神经疾病可导致昼夜节律稳态的破坏，从而加重疾病的严重程度。因此，通过基于昼夜节律的方法来优化当前的治疗方法，包括调整剂量、改变生活方式和靶向干预，为更好的临床结果和精准医学提供了有前途的机会。在这篇综述中，我们通过从实验室到临床的方法提供了昼夜节律在神经疾病中的详细影响。此外，基于不理想的临床结果，我们批判性地讨论了基于昼夜节律的干预措施的潜力，这可能会鼓励更多的这一学科的研究，希望能提高神经疾病的治疗效果。
