Murphy J E, Stewart R B, Springer P K
Am J Hosp Pharm. 1980 Apr;37(4):550-2.
An apparent case of carbamazepine-induced leukocytosis in a 26-year-old woman is presented. When admitted for psychiatric evaluation, the patient had been receiving carbamazepine for seizures for some time. A hemogram revealed a white blood cell (WBC) count of 21.2 x 10(3)/cu mm. Five days after the patient's medication was changed from carbamazepine (600 mg/day) to phenytoin (400 mg/day) and phenobarbital (120 mg/day), her WBC count was within normal range. When she experienced dizziness and ataxia, the phenytoin and phenobarbital were replaced with carbamazepine (600 mg/day). WBC counts performed 11 and 13 days after resumption of carbamazepine therapy again were significantly elevated. Other drugs administered during hospitalization included chlorpromazine, acetaminophen, and codeine. The possible causes of and pathophysiology of leukocytosis are reviewed. The changes in WBC that occurred with the rechallenge of carbamazepine indicate that the drug was the probable cause of the leukocytosis.
本文介绍了一名26岁女性卡马西平诱发白细胞增多症的明显病例。因精神科评估入院时，该患者已服用卡马西平治疗癫痫一段时间。血常规显示白细胞（WBC）计数为21.2×10³/立方毫米。在患者的药物从卡马西平（600毫克/天）更换为苯妥英钠（400毫克/天）和苯巴比妥（120毫克/天）五天后，其白细胞计数恢复正常。当她出现头晕和共济失调时，苯妥英钠和苯巴比妥被卡马西平（600毫克/天）取代。再次恢复卡马西平治疗11天和13天后进行的白细胞计数再次显著升高。住院期间使用的其他药物包括氯丙嗪、对乙酰氨基酚和可待因。本文回顾了白细胞增多症的可能病因及病理生理学。卡马西平再次激发时白细胞的变化表明该药物可能是白细胞增多症的病因。
