Bates P C, Chew L F, Millward D J
Nutrition Research Unit, London School of Hygiene and Tropical Medicine.
J Endocrinol. 1987 Sep;114(3):373-81. doi: 10.1677/joe.0.1140373.
The effects of the anabolic steroid stanozolol on whole body and muscle growth and protein metabolism in the rat have been examined. No responses could be found in normal well-fed male rats. Female rats responded to 1 mg/kg per day with an increased body and skeletal muscle growth rate and an increase in muscle protein synthesis. The anabolic action on muscle protein synthesis was due to increased RNA concentration with no change in the rate of protein synthesis per unit RNA (KRNA). Investigation of any anticatabolic effects of stanozolol treatment in male rats deprived of food for 24 h indicated no response of protein balance and turnover. However, rats treated with catabolic doses of corticosterone (50 mg/kg per day) did respond to stanozolol with decreased muscle growth inhibition due to better-maintained muscle protein synthesis. The latter response was due to a reversal of the corticosterone-induced reduction of KRNA, but with no effect on RNA concentration. Thus there appear to be at least two effects of stanozolol; an anabolic action evident only in female rats, involving increased muscle RNA concentrations, and an anticatabolic action involving inhibition of the corticosterone-induced fall in muscle RNA activity. In both cases, stanozolol influenced muscle protein synthesis with no evident effects on protein degradation.
已对合成代谢类固醇司坦唑醇对大鼠全身及肌肉生长和蛋白质代谢的影响进行了研究。在正常营养良好的雄性大鼠中未发现有反应。雌性大鼠对每天1毫克/千克的剂量有反应，其体重和骨骼肌生长速率增加，肌肉蛋白质合成增加。对肌肉蛋白质合成的合成代谢作用是由于RNA浓度增加，而单位RNA（KRNA）的蛋白质合成速率没有变化。对禁食24小时的雄性大鼠进行司坦唑醇治疗的任何抗分解代谢作用的研究表明，蛋白质平衡和周转没有反应。然而，用分解代谢剂量的皮质酮（每天50毫克/千克）治疗的大鼠确实对司坦唑醇有反应，由于肌肉蛋白质合成得到更好的维持，肌肉生长抑制作用降低。后一种反应是由于皮质酮诱导的KRNA降低的逆转，但对RNA浓度没有影响。因此，司坦唑醇似乎至少有两种作用；一种合成代谢作用仅在雌性大鼠中明显，涉及肌肉RNA浓度增加，另一种抗分解代谢作用涉及抑制皮质酮诱导的肌肉RNA活性下降。在这两种情况下，司坦唑醇都影响肌肉蛋白质合成，而对蛋白质降解没有明显影响。
