胰岛素、皮质酮及其他因素在给饥饿大鼠重新喂食后肌肉蛋白质合成急性恢复过程中的作用
The role of insulin, corticosterone and other factors in the acute recovery of muscle protein synthesis on refeeding food-deprived rats.
作者信息
Millward D J, Odedra B, Bates P C
出版信息
Biochem J. 1983 Dec 15;216(3):583-7. doi: 10.1042/bj2160583.
Abstract
Measurements of changes in muscle protein synthesis, insulin and corticosterone in vivo in refed food-deprived rats, some after pretreatment with anti-insulin serum or corticosterone, indicate that the acute increase in protein synthesis (20-40 min) requires (a) insulin, (b) a fall in corticosterone, since corticosterone acts at least in part by blocking insulin action, and (c) at least one other independent anabolic factor.
摘要
对重新喂食的饥饿大鼠体内肌肉蛋白质合成、胰岛素和皮质酮变化的测量表明，一些大鼠在预先用抗胰岛素血清或皮质酮处理后，蛋白质合成的急性增加（20 - 40分钟）需要：（a）胰岛素，（b）皮质酮下降，因为皮质酮至少部分通过阻断胰岛素作用发挥作用，以及（c）至少一种其他独立的合成代谢因子。
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