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黑色素瘤患者血浆中黑色素瘤细胞衍生外泌体的免疫抑制功能

Immunosuppressive functions of melanoma cell-derived exosomes in plasma of melanoma patients.

作者信息

Whiteside Theresa L

机构信息

Depts of Pathology, Immunology and Otolaryngology, University of Pittsburgh School of Medicine and UPMC Hillman Cancer Center, Pittsburgh, PA, United States.

出版信息

Front Cell Dev Biol. 2023 Jan 6;10:1080925. doi: 10.3389/fcell.2022.1080925. eCollection 2022.

DOI:10.3389/fcell.2022.1080925
PMID:36684448
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9853022/
Abstract

Tumor-derived exosomes (TEX) are a subset of small extracellular vesicles (sEV) present in all body fluids of patients with cancer. In plasma of patients with metastatic melanoma, numbers of exosomes produced by melanoma cells called MTEX are elevated. To study the role of MTEX in melanoma progression, immunoaffinity-based separation of MTEX from total plasma exosomes was performed. The surface of MTEX was decorated by various checkpoint inhibitory proteins, and upon coincubation with immune recipient cells, MTEX suppressed anti-tumor functions of these cells. MTEX emerge as a major mechanism of immune suppression in melanoma and thus might play a role in promoting melanoma progression.

摘要

肿瘤衍生外泌体（TEX）是存在于癌症患者所有体液中的小细胞外囊泡（sEV）的一个子集。在转移性黑色素瘤患者的血浆中，由黑色素瘤细胞产生的称为MTEX的外泌体数量会升高。为了研究MTEX在黑色素瘤进展中的作用，进行了基于免疫亲和从总血浆外泌体中分离MTEX的操作。MTEX的表面由各种检查点抑制蛋白修饰，并且在与免疫受体细胞共孵育时，MTEX会抑制这些细胞的抗肿瘤功能。MTEX成为黑色素瘤免疫抑制的主要机制，因此可能在促进黑色素瘤进展中发挥作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d5f/9853022/bb2bfebfb029/fcell-10-1080925-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d5f/9853022/b3b36c82bdda/fcell-10-1080925-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d5f/9853022/b35d7fcff749/fcell-10-1080925-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d5f/9853022/bb2bfebfb029/fcell-10-1080925-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d5f/9853022/b3b36c82bdda/fcell-10-1080925-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d5f/9853022/b35d7fcff749/fcell-10-1080925-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5d5f/9853022/bb2bfebfb029/fcell-10-1080925-g003.jpg

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Int J Mol Sci. 2022 Oct 19;23(20):12513. doi: 10.3390/ijms232012513.
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Single-cell analysis of a tumor-derived exosome signature correlates with prognosis and immunotherapy response.肿瘤来源外泌体特征的单细胞分析与预后和免疫治疗反应相关。
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Inactivation of EMILIN-1 by Proteolysis and Secretion in Small Extracellular Vesicles Favors Melanoma Progression and Metastasis.
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