Lewis P R, Galvin P M, Short R V
Department of Physiology, Monash University, Melbourne, Australia.
J Endocrinol. 1987 Oct;115(1):177-81. doi: 10.1677/joe.0.1150177.
Oestriol and progesterone concentrations were measured by specific radioimmunoassays in the saliva of six women on a daily basis during the last month of pregnancy, at frequent intervals during labour and daily during the puerperium. Salivary steroid concentrations are thought to reflect the circulating concentrations of the free hormone, and hence may be more biologically relevant than the total plasma concentration, or the urinary excretion of a metabolite. There was no sign of a fall in salivary oestriol or progesterone concentrations before the onset of labour. During the first and second stages, the concentrations fluctuated widely, perhaps due to alterations in uterine blood flow. After delivery of the placenta, hormone concentrations declined abruptly. Oestriol reached undetectable levels of less than 0.1 nmol/l within a day, whereas progesterone concentrations declined somewhat more slowly, approaching follicular-phase values after 2-3 days. This slower decline in the concentration of progesterone may be due to a leaching-out of the hormone from body fat stores. The absence of any prepartum progesterone withdrawal presumably explains the characteristic postpartum delay in the onset of lactogenesis.
在妊娠最后一个月，每天对6名女性的唾液进行检测，通过特定放射免疫测定法测量雌三醇和孕酮浓度；分娩期间每隔一段时间检测一次；产褥期每天检测一次。唾液类固醇浓度被认为反映了游离激素的循环浓度，因此可能比总血浆浓度或代谢物的尿排泄量在生物学上更具相关性。在分娩开始前，唾液中雌三醇或孕酮浓度没有下降的迹象。在第一和第二产程中，浓度波动很大，这可能是由于子宫血流的改变。胎盘娩出后，激素浓度急剧下降。雌三醇在一天内降至低于0.1 nmol/l的检测不到水平，而孕酮浓度下降得稍慢一些，2 - 3天后接近卵泡期值。孕酮浓度下降较慢可能是由于该激素从体内脂肪储存中渗出。产前孕酮没有任何撤退现象，这大概解释了产后泌乳开始延迟的特征。
