孕晚期唾液（游离）雌三醇与孕酮比值升高：雌三醇在启动人类自然分娩中起作用？
Increasing saliva (free) oestriol to progesterone ratio in late pregnancy: a role for oestriol in initiating spontaneous labour in man?
作者信息
McGarrigle H H, Lachelin G C
出版信息
Br Med J (Clin Res Ed). 1984 Aug 25;289(6443):457-9. doi: 10.1136/bmj.289.6443.457.
Abstract
Oestriol and progesterone concentrations were measured in samples of saliva obtained daily from six normal women during the final four weeks before the spontaneous onset of labour. Progesterone concentrations were found to plateau whereas oestriol concentrations continued to rise so that the mean ratio of saliva oestriol to progesterone increased from 0.80 to 1.43 between 29 days and one day before labour. Saliva oestriol concentrations were 15 times higher than saliva oestradiol concentrations. As saliva steroid concentrations reflect the unbound unconjugated (free) plasma steroid concentrations these data suggest that a changing ratio of oestriol to progesterone may play a part in initiating spontaneous labour in man.
摘要
在六名正常女性自然分娩前的最后四周，每天采集唾液样本，测量其中雌三醇和孕酮的浓度。结果发现孕酮浓度趋于平稳，而雌三醇浓度持续上升，因此在分娩前29天至1天期间，唾液中雌三醇与孕酮的平均比值从0.80升至1.43。唾液中雌三醇的浓度比雌二醇的浓度高15倍。由于唾液类固醇浓度反映了未结合的非共轭（游离）血浆类固醇浓度，这些数据表明，雌三醇与孕酮比值的变化可能在人类自然分娩的启动过程中发挥作用。
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