手性联烯酮与烯烃的立体选择性[2+2]环加成反应：在苯并环丁烯和内型双环二烯酸合成中的应用
Stereoselective [2+2]-Cycloadditions of chiral allenic ketones and alkenes: Applications towards the synthesis of benzocyclobutenes and endiandric acids.
作者信息
Guo Renyu, Witherspoon Brittany P, Brown M Kevin
机构信息
Indiana University, Department of Chemistry, 800 E. Kirkwood Ave., Bloomington, IN, 47405, USA.
出版信息
Tetrahedron. 2022 Sep 10;122. doi: 10.1016/j.tet.2022.132932. Epub 2022 Aug 8.
Abstract
Cyclobutanes are important motifs that have found utility in many contexts. Prior work has demonstrated an enantioselective isomerization/stereoselective [2 + 2] as a means to access bicyclo [4.2.0] octanes. Herein, the utility of this method is demonstrated towards the synthesis of benzocyclobutenes and a key intermediate towards the endiandric acids.
摘要
环丁烷是一类重要的结构单元，在许多领域都有应用。先前的研究表明，对映选择性异构化/立体选择性[2 + 2]反应是制备双环[4.2.0]辛烷的一种方法。本文展示了该方法在合成苯并环丁烯以及合成对映二酸关键中间体方面的应用。
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