Department of Chemistry, The University of North Carolina at Chapel Hill, Chapel Hill, NC 27599 (USA).
Angew Chem Int Ed Engl. 2015 Apr 27;54(18):5447-50. doi: 10.1002/anie.201411737. Epub 2015 Mar 10.
A stereoselective nickel-catalyzed [2+2] cycloaddition of ene-allenes is reported. This transformation encompasses a broad range of ene-allene substrates, thus providing efficient access to fused cyclobutanes from easily accessed π-components. A simple and inexpensive first-row catalytic system comprised of [Ni(cod)2 ] and dppf was used in this process, thus constituting an attractive approach to synthetically challenging cyclobutane frameworks under mild reaction conditions.
本文报道了一种对映选择性镍催化的[2+2]环加成反应。该转化涵盖了广泛的烯丙二烯底物，因此可从易得的π-组分高效地得到稠合的环丁烷。该过程使用了简单且廉价的第一过渡金属催化体系[Ni(cod)2]和 dppf，因此在温和的反应条件下，为具有挑战性的合成环丁烷骨架提供了一种有吸引力的方法。
