Zhang Shan-Shan, Zhang Niu-Niu, Guo Tian-Tian, Sheen Lee-Yan, Ho Chi-Tang, Bai Nai-Sheng
College of Chemical Engineering, Department of Pharmaceutical Engineering, Northwest University, 229 Taibai North Road, Xi'an, Shaanxi, 710069, China.
College of Food Science and Technology, Northwest University, 229 Taibai North Road, Xi'an, Shaanxi, 710069, China.
J Tradit Complement Med. 2022 Oct 12;13(1):30-38. doi: 10.1016/j.jtcme.2022.10.004. eCollection 2023 Jan.
L. is a medicinal plant with a long history. Phyto-cannabinoids are a class of compounds from L. with varieties of structures. Endocannabinoids exist in the human body. This article provides an overview of natural cannabinoids (phyto-cannabinoids and endocannabinoids) with an emphasis on their pharmacology activities.
The keywords " L″, "cannabinoids", and "central nervous system (CNS) diseases" were used for searching and collecting pieces of literature from PubMed, ScienceDirect, Web of Science, and Google Scholar. The data were extracted and analyzed to explore the effects of cannabinoids on CNS diseases.
In this paper, schematic diagrams are used to intuitively show the phyto-cannabinoids skeletons' mutual conversion and pharmacological activities, with special emphasis on their relevant pharmacological activities on central nervous system (CNS) diseases. It was found that the endocannabinoid system and microglia play a crucial role in the treatment of CNS diseases. In the past few years, pharmacological studies focused on Δ-THC, CBD, and the endocannabinoids system. It is expected to encourage new studies on a more deep exploration of other types of cannabinoids and the mechanism of their pharmacological activities in the future.
L. 是一种有着悠久历史的药用植物。植物大麻素是一类来自L. 的具有多种结构的化合物。内源性大麻素存在于人体中。本文概述了天然大麻素（植物大麻素和内源性大麻素），重点介绍了它们的药理活性。
使用关键词“L”、“大麻素”和“中枢神经系统（CNS）疾病”在PubMed、ScienceDirect、科学网和谷歌学术上搜索和收集文献。提取并分析数据以探索大麻素对中枢神经系统疾病的影响。
本文使用示意图直观地展示了植物大麻素骨架的相互转化和药理活性，特别强调了它们对中枢神经系统（CNS）疾病的相关药理活性。研究发现，内源性大麻素系统和小胶质细胞在中枢神经系统疾病的治疗中起着至关重要的作用。在过去几年中，药理学研究集中在Δ-THC、CBD和内源性大麻素系统上。预计未来会鼓励开展新的研究，以更深入地探索其他类型的大麻素及其药理活性机制。
