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未在精神分裂症患者血清中检测到多巴胺受体IgG自身抗体。简短报告。

Failure to detect dopamine receptor IgG autoantibodies in sera of schizophrenic patients. Short note.

作者信息

von Kirchbach A, Fischer E G, Kornhuber H H

机构信息

Neurologische Universitätsklinik, Ulm, Federal Republic of Germany.

出版信息

J Neural Transm. 1987;70(1-2):175-9. doi: 10.1007/BF01252518.

DOI:10.1007/BF01252518
PMID:3668519
Abstract

Autoantibodies against dopamine receptors in schizophrenic patients have been postulated. IgG was fractionated from sera of 15 schizophrenic patients (DSM III) in an acute episode. However, 3H-spiperone binding to dopamine receptors was not inhibited by this fraction.

摘要

已有研究推测精神分裂症患者体内存在针对多巴胺受体的自身抗体。从15例处于急性发作期的精神分裂症患者（DSM-III标准）血清中分离出免疫球蛋白G（IgG）。然而，该组分并未抑制3H-螺哌隆与多巴胺受体的结合。

相似文献

1
Failure to detect dopamine receptor IgG autoantibodies in sera of schizophrenic patients. Short note.未在精神分裂症患者血清中检测到多巴胺受体IgG自身抗体。简短报告。
J Neural Transm. 1987;70(1-2):175-9. doi: 10.1007/BF01252518.
2
Elevation of brain neuroleptic/dopamine receptors in schizophrenia.精神分裂症患者大脑中神经安定剂/多巴胺受体水平升高。
Am J Psychiatry. 1980 Feb;137(2):191-7. doi: 10.1176/ajp.137.2.191.
3
Abnormal neuroleptic/dopamine receptors in schizophrenia.精神分裂症中异常的抗精神病药物/多巴胺受体。
Adv Biochem Psychopharmacol. 1980;21:435-42.
4
Dopamine and schizophrenia.多巴胺与精神分裂症。
Hosp Community Psychiatry. 1991 Apr;42(4):429. doi: 10.1176/ps.42.4.429-a.
5
Dopamine receptors, neuroleptics, and schizophrenia.多巴胺受体、抗精神病药物与精神分裂症
Am J Psychiatry. 1981 Apr;138(4):460-4. doi: 10.1176/ajp.138.4.460.
6
Are dopamine receptors present on human lymphocytes?人类淋巴细胞上存在多巴胺受体吗？
J Pharm Pharmacol. 1982 Oct;34(10):658-63. doi: 10.1111/j.2042-7158.1982.tb04696.x.
7
A comparative study of [3H]haloperidol and [3H]spiroperidol binding to receptors on rat cerebral membranes.[3H]氟哌啶醇与[3H]螺哌啶醇结合大鼠脑膜受体的比较研究。
FEBS Lett. 1978 Mar 1;87(1):152-6. doi: 10.1016/0014-5793(78)80155-0.
8
Regional displacement by sulpiride of [3H]spiperone binding in vivo. Biochemical and behavioural evidence for a preferential action of limbic and nigral dopamine receptors.舒必利对体内[3H]螺哌隆结合的区域置换。边缘系统和黑质多巴胺受体优先作用的生化和行为学证据。
Neurosci Lett. 1979 Jun;13(1):51-6. doi: 10.1016/0304-3940(79)90074-0.
9
Sigma opiates and certain antipsychotic drugs mutually inhibit (+)-[3H] SKF 10,047 and [3H]haloperidol binding in guinea pig brain membranes.西格玛阿片类药物和某些抗精神病药物在豚鼠脑膜中相互抑制（+）-[3H]SKF 10,047和[3H]氟哌啶醇的结合。
Proc Natl Acad Sci U S A. 1984 Sep;81(17):5618-21. doi: 10.1073/pnas.81.17.5618.
10
Multiple receptors for brain dopamine.大脑多巴胺的多种受体。
Proc Natl Acad Sci U S A. 1978 Mar;75(3):1153-6. doi: 10.1073/pnas.75.3.1153.

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HLA DRB1*03 as a possible common etiology of schizophrenia, Graves' disease, and type 2 diabetes.人类白细胞抗原DRB1*03作为精神分裂症、格雷夫斯病和2型糖尿病可能的共同病因。
Ann Gen Psychiatry. 2017 Feb 2;16:7. doi: 10.1186/s12991-017-0128-4. eCollection 2017.
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Antineuronal antibodies against neurotransmitter receptors and synaptic proteins in schizophrenia: current knowledge and clinical implications.精神分裂症中针对神经递质受体和突触蛋白的抗神经元抗体：当前认识与临床意义
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Autoantibodies to brain and polynucleotides in patients with schizophrenia: a puzzle.

本文引用的文献

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Quantitative determination of immunoglobulins in CSF and plasma of chronic schizophrenic patients.
Br J Psychiatry. 1981 Dec;139:513-8. doi: 10.1192/bjp.139.6.513.
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Antithymic immune factor in schizophrenia. A World Health Organization study.
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Autoimmune model of schizophrenia with special reference to antibrain antibodies.精神分裂症的自身免疫模型，特别提及抗脑抗体。
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精神分裂症患者体内针对脑和多核苷酸的自身抗体：一个谜团。
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Lancet. 1982 Nov 13;2(8307):1073-6. doi: 10.1016/s0140-6736(82)90007-1.
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Antithymic antibodies in schizophrenic sera.精神分裂症患者血清中的抗胸腺抗体。
Biol Psychiatry. 1982 Jun;17(6):699-710.
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Immunoglobulins in psychiatric patients.精神病患者体内的免疫球蛋白
Arch Gen Psychiatry. 1969 Mar;20(3):272-7. doi: 10.1001/archpsyc.1969.01740150016003.
7
Increased IgA in schizophrenic patients.精神分裂症患者的IgA升高。
Lancet. 1970 Aug 15;2(7668):370. doi: 10.1016/s0140-6736(70)92909-0.
8
Schizophrenia as an immunologic disorder. I. Demonstration of antibrain globulins by fluorescent antibody techniques.
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9
Altered white cell count, protein concentration and oligoclonal IgG bands in the cerebrospinal fluid of many patients with acute psychiatric disorders.许多急性精神障碍患者的脑脊液中白细胞计数、蛋白质浓度和寡克隆IgG带发生改变。
Neuropsychobiology. 1985;14(1):1-4. doi: 10.1159/000118192.
10
Permeability of the blood-brain barrier in psychiatric patients.
Am J Psychiatry. 1985 May;142(5):657-8. doi: 10.1176/ajp.142.5.657.