豚鼠胃泌素释放肽的一级结构和组织分布

Primary structure and tissue distribution of guinea pig gastrin-releasing peptide.

作者信息

Shaw C, Thim L, Conlon J M

机构信息

Clinical Research Group for Gastrointestinal Endocrinology of the Max-Planck-Gesellschaft, University of Göttingen, F.R.G.

出版信息

J Neurochem. 1987 Nov;49(5):1348-54. doi: 10.1111/j.1471-4159.1987.tb00998.x.

DOI:10.1111/j.1471-4159.1987.tb00998.x

PMID:3668528

Abstract

The primary structure of gastrin-releasing peptide from the guinea pig stomach has been determined by automated Edman degradation and shown to be identical to porcine gastrin-releasing peptide. Extracts of guinea pig brain and small intestine contained both gastrin-releasing peptide and its COOH-terminal decapeptide (neuromedin C) but the stomach extracts contained only gastrin-releasing peptide. Within the small intestine, highest concentrations of gastrin-releasing peptide-like immunoreactivity were found in extracts of the circular and longitudinal smooth muscle layers.

摘要

通过自动埃德曼降解法确定了豚鼠胃中胃泌素释放肽的一级结构，结果表明它与猪胃泌素释放肽相同。豚鼠脑和小肠提取物中既含有胃泌素释放肽及其羧基末端十肽（神经介素C），但胃提取物中仅含有胃泌素释放肽。在小肠内，环形和纵行平滑肌层提取物中胃泌素释放肽样免疫反应性的浓度最高。