Minamino N, Kangawa K, Matsuo H
Biochem Biophys Res Commun. 1984 Feb 29;119(1):14-20. doi: 10.1016/0006-291x(84)91611-5.
From a side fraction obtained in our previous isolation of neuromedin B from porcine spinal cord, we have purified another decapeptide that exhibits a potent stimulant effect on the smooth muscle preparation of rat uterus. By microsequencing and synthesis, the amino acid sequence of the peptide has been identified as: Gly-Asn-His-Trp-Ala-Val-Gly-His-Leu-Met-NH2. This peptide is found to be identical with the carboxy-terminal subsequence [18-27] of gastrin releasing peptide, and to display a potent contractile activity on rat uterus in the characteristic manner of bombesin. These facts strongly suggest that the peptide may be a neuromediator in the neural communication systems of mammals. We propose the name "neuromedin C" for this peptide, since it is closely related to "neuromedin B", recently identified as a bombesin-like mammalian peptide.
从我们先前从猪脊髓中分离神经降压素B时获得的一个侧级分中，我们纯化出了另一种十肽，它对大鼠子宫的平滑肌制剂表现出强烈的刺激作用。通过微量测序和合成，该肽的氨基酸序列已被确定为：甘氨酸-天冬酰胺-组氨酸-色氨酸-丙氨酸-缬氨酸-甘氨酸-组氨酸-亮氨酸-甲硫氨酸-氨基。发现该肽与胃泌素释放肽的羧基末端亚序列[18-27]相同，并以蛙皮素的特征方式对大鼠子宫表现出强烈的收缩活性。这些事实有力地表明，该肽可能是哺乳动物神经通讯系统中的一种神经介质。由于它与最近被鉴定为一种类蛙皮素的哺乳动物肽的“神经降压素B”密切相关，我们为此肽提议命名为“神经介质C”。
