Postgraduate Program in Biology Applied to Health, Center of Biosciences, Federal University of Pernambuco, Recife, Brazil.
Postgraduate Program in Surgery, Center for Medical Sciences, Federal University of Pernambuco, Recife, Brazil.
Front Immunol. 2023 Jan 4;13:1051059. doi: 10.3389/fimmu.2022.1051059. eCollection 2022.
COVID-19 is an infectious disease caused by the SARS-CoV-2 virus, which induces a high release of pro-inflammatory chemokines and cytokines, leading to severe systemic disorders. Further, evidence has shown that recovered COVID-19 patients still have some symptoms and disorders from COVID-19. Physical exercise can have many health benefits. It is known to be a potent regulator of the immune system, which includes frequency, intensity, duration, and supervised by a professional. Given the confinement and social isolation or hospitalization of COVID-19 patients, the population became sedentary or opted for physical exercise at home, assuming the guarantee of the beneficial effects of physical exercise and reducing exposure to SARS-CoV-2. This study aimed to investigate the effects of a supervised exercise protocol and a home-based unsupervised exercise protocol on chemokine and cytokine serum levels in recovered COVID-19 patients. This study was a prospective, parallel, two-arm clinical trial. Twenty-four patients who had moderate to severe COVID-19 concluded the intervention protocols of this study. Participants were submitted to either supervised exercise protocol at the Clinical Hospital of the Federal University of Pernambuco or home-based unsupervised exercise for 12 weeks. We analyzed serum levels of chemokines (CXCL8/IL-8, CCL5/RANTES, CXCL9/MIG, CCL2/MCP-1, and CXCL10/IP-10) and cytokines (IL-2, IL-4, IL-6, IL-10, IL-17A, TNF-α, and IFN-γ). Before the interventions, no significant differences were observed in the serum levels of chemokines and cytokines between the supervised and home-based unsupervised exercise groups. The CXCL8/IL-8 ( = 0.04), CCL2/MCP-1 ( = 0.03), and IFN-γ ( = 0.004) levels decreased after 12 weeks of supervised exercise. In parallel, an increase in IL-2 ( = 0.02), IL-6 ( = 0.03), IL-4 ( = 0.006), and IL-10 ( = 0.04) was observed after the supervised protocol compared to pre-intervention levels. No significant differences in all the chemokines and cytokines were found after 12 weeks of the home-based unsupervised exercise protocol. Given the results, the present study observed that supervised exercise was able to modulate the immune response in individuals with post-COVID-19, suggesting that supervised exercise can mitigate the inflammatory process associated with COVID-19 and its disorders.
https://ensaiosclinicos.gov.br/rg/RBR-7z3kxjk, identifier U1111-1272-4730.
COVID-19 是由 SARS-CoV-2 病毒引起的传染病，它会引起大量促炎趋化因子和细胞因子的释放，导致严重的全身紊乱。此外，有证据表明，康复的 COVID-19 患者仍有一些 COVID-19 症状和疾病。体育锻炼有许多健康益处。众所周知，它是免疫系统的有力调节剂，包括频率、强度、持续时间和由专业人员监督。鉴于 COVID-19 患者的禁闭和社会隔离或住院，人们变得久坐不动或选择在家进行体育锻炼，假设可以保证体育锻炼的有益效果，并减少接触 SARS-CoV-2。本研究旨在探讨监督运动方案和家庭监督运动方案对康复 COVID-19 患者趋化因子和细胞因子血清水平的影响。本研究是一项前瞻性、平行、双臂临床试验。24 名患有中度至重度 COVID-19 的患者完成了本研究的干预方案。参与者接受了联邦大学临床医院的监督运动方案或家庭监督运动方案 12 周。我们分析了趋化因子（CXCL8/IL-8、CCL5/RANTES、CXCL9/MIG、CCL2/MCP-1 和 CXCL10/IP-10）和细胞因子（IL-2、IL-4、IL-6、IL-10、IL-17A、TNF-α和 IFN-γ）的血清水平。在干预之前，监督和家庭监督运动组之间趋化因子和细胞因子的血清水平没有显著差异。12 周监督运动后，CXCL8/IL-8（=0.04）、CCL2/MCP-1（=0.03）和 IFN-γ（=0.004）水平下降。同时，与干预前相比，监督方案后观察到 IL-2（=0.02）、IL-6（=0.03）、IL-4（=0.006）和 IL-10（=0.04）增加。12 周家庭监督运动方案后，所有趋化因子和细胞因子均无显著差异。考虑到这些结果，本研究观察到监督运动能够调节 COVID-19 后个体的免疫反应，表明监督运动可以减轻 COVID-19 及其疾病相关的炎症过程。
https://ensaiosclinicos.gov.br/rg/RBR-7z3kxjk，标识符 U1111-1272-4730。
