Department of Infectious Diseases and Clinical Microbiology, Atatürk University School of Medicine, Erzurum, Turkey.
Department of Biochemistry, Faculty of Medicine, Ataturk University, Erzurum, Turkey.
Int J Clin Pract. 2021 Dec;75(12):e14970. doi: 10.1111/ijcp.14970. Epub 2021 Oct 22.
COVID 19 was first observed in December 2019 and has affected the world entire. Effective laboratory markers and prognostic indicators are needed to predict the clinical progression of the disease.
The purpose of this study was to investigate IL6, IL8/CXCL8, and IP10/CXCL10, and biochemical parameters associated with SARS, MERS, and SARS-CoV-2 infections and their significance on prognosis in healthy volunteers and mild-moderate and severe COVID 19 patients.
Healthy volunteers (n = 30), and patients with mild-moderate (n = 30) and severe (n = 30) COVID-19 patients were included in the study. IL-6, IL-8, and IP-10 levels and biochemical parameters were assessed among the groups and their correlations with each other were subjected to statistical analysis.
Blood serum IL-6, IL-8, and IP-10 levels were the highest in the severe patient group (P = .001), and also higher in the mild-moderate group as compared with the healthy volunteers (P = .001). Statistically significant positive correlations were identified between serum IL-8 and IL-6 levels (P = .001, r = 0.660), between serum IP-10 and IL-6 (P = .001, r = 0.599) and between serum IP-10 and IL-8 (P = .001, r = 0.729).
A statistically significant difference was found in WBC, NE%, NE, LY%, LY, HB, BUN, total protein, albumin, d-dimer, sedimentation differed significantly between the groups. Biomarkers of potential significance in terms of the severity of COVID 19 disease were examined, and high IL-6, IL-8, IP-10, CRP, PCT, and LY parameters values emerged as associated with the severity of the disease.
COVID-19 于 2019 年 12 月首次被发现，已对全球造成影响。需要有效的实验室标志物和预后指标来预测疾病的临床进展。
本研究旨在探讨白细胞介素 6（IL-6）、白细胞介素 8（IL-8）/趋化因子配体 8（CXCL8）和干扰素诱导蛋白 10（IP-10）/趋化因子配体 10（CXCL10），以及与 SARS、MERS 和 SARS-CoV-2 感染相关的生化参数，及其在健康志愿者和 COVID-19 轻症-中度和重症患者中的预后意义。
本研究纳入了 30 名健康志愿者和 30 名 COVID-19 轻症-中度患者以及 30 名 COVID-19 重症患者。评估了各组之间的 IL-6、IL-8 和 IP-10 水平以及生化参数，并对它们之间的相关性进行了统计学分析。
血清 IL-6、IL-8 和 IP-10 水平在重症患者组中最高（P=0.001），且在轻症-中度患者组中也高于健康志愿者（P=0.001）。血清 IL-8 与 IL-6 水平之间（P=0.001，r=0.660）、血清 IP-10 与 IL-6 之间（P=0.001，r=0.599）以及血清 IP-10 与 IL-8 之间（P=0.001，r=0.729）存在显著的正相关关系。
白细胞（WBC）、中性粒细胞百分比（NE%）、中性粒细胞（NE）、淋巴细胞百分比（LY%）、淋巴细胞（LY）、血红蛋白（HB）、血尿素氮（BUN）、总蛋白、白蛋白、D-二聚体、沉降率在各组之间存在显著差异。研究了 COVID-19 疾病严重程度方面具有潜在意义的生物标志物，发现高 IL-6、IL-8、IP-10、C 反应蛋白（CRP）、降钙素原（PCT）和 LY 参数值与疾病的严重程度相关。
