Musheyev Yakubmiyer, Fazylov Michail, Abramowitz Chiya, Ikhuoriah Teddy A, Rogu Peter, Levada Maria
Medicine, New York Institute of Technology College of Osteopathic Medicine, Old Westbury, USA.
Obstetrics and Gynaecology, New York Institute of Technology College of Osteopathic Medicine, Old Westbury, USA.
Cureus. 2022 Dec 19;14(12):e32698. doi: 10.7759/cureus.32698. eCollection 2022 Dec.
Mucosal melanomas (MM) are a rare type of melanomas commonly found in the vulvovaginal, anorectal, and respiratory tract. In this case report, a 71-year-old female presented to her OB/GYN clinic with dark raised mass on her right labial region adjacent to the perineum. Past medical and surgical history of note included third-degree uterine prolapse, senile vaginitis, fibrocystic changes of the breasts bilaterally, hypothyroidism, hypertension, as well as a past hysterectomy and anterior colporrhaphy. Upon further workup, the 2.7 x 1.8 x 2 cm polyploid mass was biopsied and was found to be consistent with malignant melanoma. The patient then underwent a wide local excision confirming that the lesion was a nodular vulvar melanoma with superficial ulcerations and lymphovascular invasion of the vulvar region. Post-wide local incisions were found to be healed well after the procedure and the patient was referred to a gynecological oncologist for continuous monitoring. The purpose of this case report is to bring awareness of melanomas arising in atypical regions. While MMs are rare in comparison to cutaneous melanomas (CM), the prognosis can be poor if not caught early.
黏膜黑色素瘤（MM）是一种罕见的黑色素瘤类型，常见于外阴阴道、肛门直肠和呼吸道。在本病例报告中，一名71岁女性因右阴唇区域靠近会阴处有深色隆起肿物就诊于妇产科诊所。值得注意的既往病史和手术史包括三度子宫脱垂、老年性阴道炎、双侧乳腺纤维囊性变、甲状腺功能减退、高血压，以及既往子宫切除术和阴道前壁修补术。经进一步检查，对这个2.7×1.8×2厘米的多倍体肿物进行活检，结果发现与恶性黑色素瘤相符。随后患者接受了广泛局部切除术，证实该病变为结节性外阴黑色素瘤，伴有浅表溃疡和外阴区域的淋巴管浸润。广泛局部切除术后切口愈合良好，患者被转诊至妇科肿瘤学家处进行持续监测。本病例报告的目的是提高对非典型部位发生黑色素瘤的认识。虽然与皮肤黑色素瘤（CM）相比，MM较为罕见，但如果不及早发现，预后可能较差。
