继发于视网膜中央动脉阻塞的急性黄斑神经视网膜病变。
Acute macular neuroretinopathy secondary to central retinal artery occlusion.
作者信息
Sarrasin Emérentienne, Malclès Ariane, Sarraf David
机构信息
Department of Ophthalmology, Geneva University Hospitals, Geneva, Switzerland.
Faculty of Medicine, University of Geneva, Geneva, Switzerland.
出版信息
Am J Ophthalmol Case Rep. 2023 Jan 5;29:101793. doi: 10.1016/j.ajoc.2023.101793. eCollection 2023 Mar.
PURPOSE
Acute Macular Neuroretinopathy (AMN) may be the result of deep retinal capillary plexus (DCP) impairment, but its mechanism remains elusive. A recent study has described simultaneous onset of Paracentral Acute Middle Maculopathy (PAMM) and AMN, suggesting a related pathogenic pathway. In this report, we analyze and describe the imaging characteristics of patients with concomitant Central Retinal Artery Occlusion (CRAO) and AMN and suggest a mechanistic pathway to explain this relationship.
OBSERVATIONS
A total of 2 cases of CRAO, arteritic and non arteritic, were included in this report. At initial presentation, outer retinal layers were intact. At the two-week follow-up visit, both cases displayed Henle fiber layer hyperreflectivity and ellipsoid zone disruption consistent with AMN.
CONCLUSIONS
Secondary development of AMN in CRAO is a new finding. DCP ischemia secondary to CRAO may lead to Henle fiber layer disruption, leading to the characteristic findings of AMN.
目的
急性黄斑神经视网膜病变（AMN）可能是视网膜深层毛细血管丛（DCP）受损的结果，但其机制仍不清楚。最近一项研究描述了中心旁急性黄斑病变（PAMM）和AMN同时发病，提示存在相关的致病途径。在本报告中，我们分析并描述了合并视网膜中央动脉阻塞（CRAO）和AMN患者的影像学特征，并提出一种机制来解释这种关系。
观察结果
本报告纳入了2例CRAO患者，分别为动脉炎性和非动脉炎性。初次就诊时，视网膜外层完整。在两周的随访中，两例患者均表现出与AMN一致的Henle纤维层高反射性和椭圆体带破坏。
结论
CRAO中AMN的继发发展是一项新发现。CRAO继发的DCP缺血可能导致Henle纤维层破坏，从而导致AMN的特征性表现。
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